Molecular structure of Salazinic acid, CAS Number: 521-39-1
Salazinic acid (CAS 521-39-1)
Alternate Names:
Salacinic acid; Parmatic acid; Saxatilic acid
Application:
Salazinic acid is A metabolite with antioxidant properties.
CAS Number:
521-39-1
Purity:
≥95%
Molecular Weight:
388.3
Molecular Formula:
C18H12O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Salazinic acid, a depsidone lichen metabolite discovered in P. sulcata, exhibits notable properties. In vitro studies have revealed its activity against various microorganisms with minimum inhibitory concentrations (MICs) ranging from 3.9 to 30.8 mM. Additionally, salazinic acid demonstrates cytotoxic effects on MM98, A431, and HaCaT cells, as evidenced by crystal violet assays (with EC50s of 159, 2,870, and 48 μM, respectively) and neutral red uptake assays (with EC50s of 1,925, 1,913, and 907 μM, respectively). Notably, when used at a concentration of 30 μM, it accelerates wound closure in scratch-wounded HaCaT monolayers and enhances HaCaT cell migration in transwell assays.
Salazinic acid (CAS 521-39-1) References
- Antimicrobial activity of extracts of the lichen Parmelia sulcata and its salazinic acid constituent. | Candan, M., et al. 2007. Z Naturforsch C J Biosci. 62: 619-21. PMID: 17913083
- Ecological implication of variation in the secondary metabolites in Parmelioid lichens with respect to altitude. | Shukla, V., et al. 2016. Environ Sci Pollut Res Int. 23: 1391-7. PMID: 26370809
- Potential of Lichen Compounds as Antidiabetic Agents with Antioxidative Properties: A Review. | Thadhani, VM. and Karunaratne, V. 2017. Oxid Med Cell Longev. 2017: 2079697. PMID: 28491237
- Lichen-derived caperatic acid and physodic acid inhibit Wnt signaling in colorectal cancer cells. | Paluszczak, J., et al. 2018. Mol Cell Biochem. 441: 109-124. PMID: 28887754
- Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum. | Devi, AP., et al. 2020. Planta Med. 86: 1216-1224. PMID: 32819010
- Lichen Depsidones with Biological Interest. | Ureña-Vacas, I., et al. 2022. Planta Med. 88: 855-880. PMID: 34034351
- A Review of Anti-Cancer and Related Properties of Lichen-Extracts and Metabolites. | Tripathi, AH., et al. 2022. Anticancer Agents Med Chem. 22: 115-142. PMID: 34225637
- Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells. | Papierska, K., et al. 2021. Molecules. 26: PMID: 34443375
- Biological Effects of Gyrophoric Acid and Other Lichen Derived Metabolites, on Cell Proliferation, Apoptosis and Cell Signaling pathways. | Mohammadi, M., et al. 2022. Chem Biol Interact. 351: 109768. PMID: 34864007
- Protocetraric and Salazinic Acids as Potential Inhibitors of SARS-CoV-2 3CL Protease: Biochemical, Cytotoxic, and Computational Characterization of Depsidones as Slow-Binding Inactivators. | Fagnani, L., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 35745633
- Histological evaluation of the liver of mice with sarcoma-180 treated with salazinic acid. | Lira, MADC., et al. 2023. An Acad Bras Cienc. 95: e20200455. PMID: 37018833
- Assessment of Cytotoxic/Antitumour Potential and in Silico Study of Salazinic Acid Isolated from Parmotrema concurrens. | de Lira, MADC., et al. 2023. Anticancer Agents Med Chem.. PMID: 37032502
- Salazinic acid attenuates male sexual dysfunction and testicular oxidative damage in streptozotocin-induced diabetic albino rats. | Killari, KN., et al. 2023. RSC Adv. 13: 12991-13005. PMID: 37124014
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Salazinic acid, 1 mg | sc-506286 | 1 mg | $153.00 |