Molecular structure of Saclofen, CAS Number: 125464-42-8
Saclofen (CAS 125464-42-8)
Alternate Names:
(RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
Application:
Saclofen is a selective GABAB antagonist
CAS Number:
125464-42-8
Purity:
>98%
Molecular Weight:
249.72
Molecular Formula:
C9H12CINO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Saclofen is a selective antagonist of the GABAB receptor. Saclofen demonstrates less potency than 2-hydroxysaclofen (sc-202011).
Saclofen (CAS 125464-42-8) References
- Respiratory network function in the isolated brainstem-spinal cord of newborn rats. | Ballanyi, K., et al. 1999. Prog Neurobiol. 59: 583-634. PMID: 10845755
- Neurotransmitter mechanisms in gabapentin antinociception. | Dixit, RK. and Bhargava, VK. 2002. Pharmacology. 65: 198-203. PMID: 12119449
- Thioether analogues of baclofen, phaclofen and saclofen. | Allan, RD., et al. 1990. Neurosci Lett. 112: 223-8. PMID: 2163039
- Inhibition of baclofen binding to rat cerebellar membranes by phaclofen, saclofen, 3-aminopropylphosphonic acid and related GABAB receptor antagonists. | Drew, CA., et al. 1990. Neurosci Lett. 113: 107-10. PMID: 2164173
- Antagonism at GABAB receptors by saclofen and related sulphonic analogues of baclofen and GABA. | Kerr, DI., et al. 1989. Neurosci Lett. 107: 239-44. PMID: 2559370
- GABAB receptors and their significance in mammalian pharmacology. | Bowery, N. 1989. Trends Pharmacol Sci. 10: 401-7. PMID: 2559518
- Antinociceptive effect of intrathecal P7C3 via GABA in a rat model of inflammatory pain. | Ryu, SW., et al. 2021. Eur J Pharmacol. 899: 174029. PMID: 33727053
Inhibitor of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Saclofen, 10 mg | sc-203252 | 10 mg | $179.00 |