SA-1 Antibody (LL-16): sc-81851
- SA-1 Antibody (LL-16) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant SA-1 of human origin
- recommended for detection of SA-1 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SA-1 Antibody (LL-16). This work is in progress.
SA-1 Antibody (LL-16) is a mouse monoclonal IgG2b antibody that detects SA-1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SA-1, also known as STAG1, is a crucial 1258 amino acid component of the cohesion complex, which plays a vital role in maintaining the cohesion of sister chromatids following DNA replication. SA-1 is primarily localized in the nucleus, where SA-1 associates with chromatin, ensuring proper chromosome alignment and separation during cell division. SA-1′s function is underscored by SA-1′s interaction with Rad21, as SA-1 is essential for the structural integrity of the cohesion complex. Upon phosphorylation by Polo-like kinase (Plk), SA-1 dissociates from chromatin, facilitating the correct segregation of chromosomes during anaphase. SA-1 is expressed in key hematopoietic tissues such as the thymus, bone marrow, and spleen, and exhibits a remarkable 99% similarity to its mouse homolog, highlighting SA-1′s evolutionary conservation and significance in cellular processes. SA-1 (LL-16) antibody is an invaluable tool for researchers studying chromosomal dynamics and cohesion mechanisms in human cells.
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SA-1 Antibody (LL-16) References:
- Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors. | Rae, FK., et al. 2001. Mol Carcinog. 32: 44-53. PMID: 11568975
- Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway. | Anazawa, Y., et al. 2004. Oncogene. 23: 7621-7. PMID: 15361841
- Prostate--specific G protein couple receptor genes and STAG1/PMEPA1 in peripheral blood from patients with prostatic cancer. | Cardillo, MR. and Di Silverio, F. 2006. Int J Immunopathol Pharmacol. 19: 871-8. PMID: 17166409
- STAG1 mutations cause a novel cohesinopathy characterised by unspecific syndromic intellectual disability. | Lehalle, D., et al. 2017. J Med Genet. 54: 479-488. PMID: 28119487
- Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts. | van der Lelij, P., et al. 2017. Elife. 6: PMID: 28691904
- Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation. | Viny, AD., et al. 2019. Cell Stem Cell. 25: 682-696.e8. PMID: 31495782
- STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers. | van der Lelij, P., et al. 2020. Life Sci Alliance. 3: PMID: 32467316
- Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells. | Arruda, NL., et al. 2020. Epigenetics Chromatin. 13: 32. PMID: 32778134
- Degradation of salicylic acid to catechol in Solanaceae by SA 1-hydroxylase. | Zhou, F., et al. 2021. Plant Physiol. 185: 876-891. PMID: 33793924
- Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2. | Alonso-Gil, D., et al. 2023. Nat Commun. 14: 1326. PMID: 36898992
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SA-1 Antibody (LL-16) | sc-81851 | 100 µg/ml | $339.00 |