Molecular structure of S63845, CAS Number: 1799633-27-4
S63845 (CAS 1799633-27-4)
CAS Number:
1799633-27-4
Molecular Weight:
829.3
Molecular Formula:
C39H37ClF4N6O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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S63845 (CAS 1799633-27-4) References
- The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. | Kotschy, A., et al. 2016. Nature. 538: 477-482. PMID: 27760111
- S63845, an MCL-1 Selective BH3 Mimetic: Another Arrow in Our Quiver. | Letai, A. 2016. Cancer Cell. 30: 834-835. PMID: 27960083
- Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia. | Bhatt, S., et al. 2020. Cancer Cell. 38: 872-890.e6. PMID: 33217342
- Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma. | Algarín, EM., et al. 2021. Cells. 10: PMID: 33806619
- Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer. | Troiani, M., et al. 2022. Nat Commun. 13: 2177. PMID: 35449130
- The mtDNA-STING pathway plays an important role in both navitoclax- and S63845-induced autophagy and enhances cell death. | Jia, J., et al. 2023. Cell Biol Toxicol. 39: 2821-2839. PMID: 37002446
- MCL-1 Inhibitor S63845 Distinctively Affects Intramedullary and Extramedullary Hematopoiesis. | Zhang, H., et al. 2023. Pharmaceutics. 15: PMID: 37111571
- SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication. | Pan, P., et al. 2023. Signal Transduct Target Ther. 8: 194. PMID: 37160897
- AKT inhibition sensitizes acute leukemia cells to S63845-induced apoptosis. | Li, Y., et al. 2023. Hematology. 28: 2214465. PMID: 37222135
- Venetoclax, alone and in combination with the BH3 mimetic S63845, depletes HIV-1 latently infected cells and delays rebound in humanized mice. | Arandjelovic, P., et al. 2023. Cell Rep Med. 4: 101178. PMID: 37652018
Inhibitor of:
Baxα, Bcl-7c, Bcl-B, Bcl-G, Bcl-rambo, Bclp2, Bfk, caspase-7, DNLC2A, FAPα, GOLT1B, Mcl-1, Mcl-1L, and MOMP.Activator of:
Bcl-2, Bcl-B, Bcl-xL, caspase-7, Hrk, and scotin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S63845, 1 mg | sc-507518 | 1 mg | $150.00 |