Molecular structure of S32826, CAS Number: 1103672-43-0
S32826 (CAS 1103672-43-0)
Application:
S32826 is a potent inhibitor of autotaxin
CAS Number:
1103672-43-0
Purity:
>98%
Molecular Weight:
441.45
Molecular Formula:
C21H34NNa2O4P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
S32826 is a potent and selective autotaxin inhibitor, inhibiting recombinant autotaxin β with an IC50 of 8.8 nM. It shows similar effectiveness against the three known autotaxin isoforms (α, β, and γ). It has no effect on a variety of receptors and enzymes, with the exceptions of src (IC50 = 6 μM) and phosphatase 1B (IC50 = 15 μM). Autotaxin is a lysophospholipase D, cleaving lysophosphatidylcholine to produce choline and lysophosphatidic acid (LPA). S32826 inhibits LPA release from adipocytes (IC50 = 90 nM) and reduces plasma autotaxin activity by 57% when used at 5 μM.
S32826 (CAS 1103672-43-0) References
- S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool. | Ferry, G., et al. 2008. J Pharmacol Exp Ther. 327: 809-19. PMID: 18755937
- Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin. | Jiang, G., et al. 2011. Bioorg Med Chem Lett. 21: 5098-101. PMID: 21489790
- Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure. | Iyer, P., et al. 2012. PLoS One. 7: e42627. PMID: 22916143
- Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor. | Fisher, N., et al. 2014. ACS Med Chem Lett. 5: 34-9. PMID: 24900771
- LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs. | Mori, S., et al. 2015. Mol Cell Biochem. 408: 147-54. PMID: 26116018
- Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells. | Hirane, M., et al. 2016. Mol Carcinog. 55: 1573-1583. PMID: 26377854
Inhibitor of:
Autotaxin, and DGK-α.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S32826, 5 mg | sc-215836 | 5 mg | $178.00 | |||
S32826, 25 mg | sc-215836A | 25 mg | $685.00 |