Molecular structure of (S)-SNAP 5114, CAS Number: 157604-55-2
(S)-SNAP 5114 (CAS 157604-55-2)
Alternate Names:
(S)-1-[2-[Tris(4-methoxyphenyl)methoxy]ethyl]-3-piperidinecarboxylic acid
Application:
(S)-SNAP 5114 is a GABA uptake inhibitor that increases thalamic GABA levels
CAS Number:
157604-55-2
Purity:
≥98%
Molecular Weight:
505.61
Molecular Formula:
C30H35NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(S)-SNAP 5114 is a GABA uptake inhibitor, showing selectivity for GABA T-3 and GABA T-2 (IC50 values are 5, 21 and 388 muM for hGABA T-3, rGABA T-2 and hGABA T-1 respectively). Increases thalamic GABA levels. For the past two decades, the synthetic compound (S)-Snap 5114 has been extensively utilized in scientific research and experimentation. This compound holds particular significance due to its chiral nature, which implies that it exists in two distinct forms that are mirror images of one another.
(S)-SNAP 5114 (CAS 157604-55-2) References
- New highly potent GABA uptake inhibitors selective for GAT-1 and GAT-3 derived from (R)- and (S)-proline and homologous pyrrolidine-2-alkanoic acids. | Fülep, GH., et al. 2006. Eur J Med Chem. 41: 809-24. PMID: 16766089
- Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2. | Christiansen, B., et al. 2007. J Biol Chem. 282: 19331-41. PMID: 17502375
- δ-Aminolevulinic acid and its methyl ester induce the formation of Protoporphyrin IX in cultured sensory neurones. | Novak, B., et al. 2011. Naunyn Schmiedebergs Arch Pharmacol. 384: 583-602. PMID: 21947250
- Development of an (S)-1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114] carba analogue inhibitor for murine γ-aminobutyric acid transporter type 4. | Pabel, J., et al. 2012. ChemMedChem. 7: 1245-55. PMID: 22544452
- Comparison of the uptake of 5-aminolevulinic acid and its methyl ester in keratinocytes and skin. | Schulten, R., et al. 2012. Naunyn Schmiedebergs Arch Pharmacol. 385: 969-79. PMID: 22801976
- Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3. | Damgaard, M., et al. 2015. ACS Chem Neurosci. 6: 1591-9. PMID: 26154082
- Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia. | Lie, ME., et al. 2018. J Cereb Blood Flow Metab. 38: 166-173. PMID: 29148909
- Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with an alkyne spacer as GABA uptake inhibitors. | Tóth, K., et al. 2018. Bioorg Med Chem. 26: 3668-3687. PMID: 29886082
- Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors. | Tóth, K., et al. 2018. Bioorg Med Chem. 26: 5944-5961. PMID: 30442505
- Generation and screening of pseudostatic hydrazone libraries derived from 5-substituted nipecotic acid derivatives at the GABA transporter mGAT4. | Hauke, TJ., et al. 2019. Bioorg Med Chem. 27: 144-152. PMID: 30503411
- N-Substituted Nipecotic Acids as (S)-SNAP-5114 Analogues with Modified Lipophilic Domains. | Böck, MC., et al. 2020. ChemMedChem. 15: 756-771. PMID: 32187815
- Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex. | Andersen, JV., et al. 2020. Glia. 68: 2601-2612. PMID: 32584476
- Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. | Borden, LA., et al. 1994. Recept Channels. 2: 207-13. PMID: 7874447
Inhibitor of:
GABA T-2, and GABA T-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-SNAP 5114, 5 mg | sc-204257 | 5 mg | $173.00 | |||
(S)-SNAP 5114, 25 mg | sc-204257A | 25 mg | $571.00 |