(S)-SNAP 5114 CAS: 157604-55-2
MF: C30H35NO6
MW: 505.61
A GABA uptake inhibitor that increases thalamic GABA levels.

(S)-SNAP 5114 (CAS 157604-55-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 116ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: (S)-1-[2-[Tris(4-methoxyphenyl)methoxy]ethyl]-3-piperidinecarboxylic acid
Application: A GABA uptake inhibitor that increases thalamic GABA levels
CAS Number: 157604-55-2
Purity: ≥98%
Molecular Weight: 505.61
Molecular Formula: C30H35NO6
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

(S)-SNAP 5114 is a GABA uptake inhibitor, showing selectivity for GABA T-3 and GABA T-2 (IC50 values are 5, 21 and 388 μM for hGABA T-3, rGABA T-2 and hGABA T-1 respectively). Increases thalamic GABA levels.


References

Borden et al (1994) Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels 2 207. Borden (1996) GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem.Int. 29 335. Dalby (2000) GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology 39 2399.

Physical State :
Solid
Solubility :
Soluble in DMSO (>5 mg/ml), and ethanol (50 mM). Insoluble in water.
Storage :
Store at -20° C
Boiling Point :
643.92° C at 760 mmHg (Predicted)
Density :
1.18 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
GABA transporter 4: IC50 = 1.55 µM (mouse); hGAT-3: IC50 = 5 µM; GABA transporter 3: IC50 = 5 µM (human); rGAT-2: IC50 = 21 µM; hGAT-1: IC50 = 388 µM
pK Values :
pKa: 3.85 (Predicted), pKb: 9.35 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6604883
MDL Number :
MFCD06411702
SMILES :
COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)OCCN4CCC[[email protected]](C4)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 121ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 49ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.