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(S)-SNAP 5114 is a GABA uptake inhibitor, showing selectivity for GABA T-3 and GABA T-2 (IC50 values are 5, 21 and 388 μM for hGABA T-3, rGABA T-2 and hGABA T-1 respectively). Increases thalamic GABA levels.
Borden et al (1994) Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels 2 207. Borden (1996) GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem.Int. 29 335. Dalby (2000) GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology 39 2399.
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