Molecular structure of (S,R,S)-AHPC-PEG3-azide, CAS Number: 1797406-80-4
(S,R,S)-AHPC-PEG3-azide (CAS 1797406-80-4)
Alternate Names:
(2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS Number:
1797406-80-4
Molecular Weight:
645.77
Molecular Formula:
C30H43N7O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
The compound (S,R,S)-AHPC-PEG3-azide serves as a component for creating ProTACs. It comprises a ligand that recruits von Hippel-Lindau (VHL) and a PEGylated crosslinker with an attached azide group, facilitating click chemistry with a target ligand. By combining this compound with other protein degrader building blocks featuring an azide group, researchers can employ parallel synthesis to efficiently produce ProTAC libraries. This approach allows for rapid exploration of variations in crosslinker length, composition, and E3 ligase ligand, enhancing the diversity and potential of the libraries.
(S,R,S)-AHPC-PEG3-azide (CAS 1797406-80-4) References
- Development of a novel PROTAC using the nucleic acid aptamer as a targeting ligand for tumor selective degradation of nucleolin. | Zhang, L., et al. 2022. Mol Ther Nucleic Acids. 30: 66-79. PMID: 36250201
- An instructive attempt on developing aptamer-constructed PROTAC for breast cancer treatment. | Zhang, Y., et al. 2022. Mol Ther Nucleic Acids. 30: 351-352. PMID: 36381581
- Current Status of Oligonucleotide-Based Protein Degraders. | Shih, PC., et al. 2023. Pharmaceutics. 15: PMID: 36986626
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S,R,S)-AHPC-PEG3-azide, 50 mg | sc-506314 | 50 mg | $525.00 |