S(−)-Propranolol hydrochloride (CAS 4199-10-4)

S(−)-Propranolol hydrochloride is a small molecule beta-AR (beta-adrenergic) receptor antagonist and the active isomer of (±)-Propranolol preparations. S(−)-Propranolol hydrochloride blocks the binding of epinephrine, norepinephrine, and other endogenous catecholamines to the beta-adrenergic receptor, impeding increases in cardiac flow velocity and general stimulation of the sympathetic nervous system signaled by association of these molecules to the beta-adrenergic receptor. In addition to blockade of agonist binding, antagonism of the beta-adrenergic receptor by S(−)-Propranolol hydrochloride produces negative chronotropic and inotropic action, effectively dampening the force and rate of cardiac contraction. These negative chronotropic and inotropic effects correlate to a demonstrated suppression of adrenaline-induced cardiac arrhythmia by S(−)-Propranolol hydrochloride. Suppression of beta-adrenergic receptor activation by S(−)-Propranolol hydrochloride has been widely exploited in counteracting situations sensitive to heightened cardiac activity including hypertension, angina pectoris, and cardiac ischemia. S(−)-Propranolol Hydrochloride is an inhibitor of SR-1A, SR-1B and SR-2C.