Molecular structure of (S)-(−)-Pindolol, CAS Number: 26328-11-0
(S)-(−)-Pindolol (CAS 26328-11-0)
See product citations (1)
Alternate Names:
(2S)-1-(1H-Indol-4-yloxy)-3-(isopropylamino)propan-2-ol
Application:
(S)-(−)-Pindolol is a SR-1A/SR-1B antagonist
CAS Number:
26328-11-0
Purity:
>99%
Molecular Weight:
248.32
Molecular Formula:
C14H20N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
(S)-(−)-Pindolol, alternatively known as (−)-pindolol, stands as a potent selective beta-adrenergic receptor blocker. Many vitro studies have been scrutinized. Due to its influence on cell cultures and enzyme activity, shedding light on its intricate mechanisms While the precise mechanism of action for (S)-(−)-Pindolol remains incompletely elucidated, it is postulated to operate by obstructing the beta-adrenergic receptors present on the cell surface.
(S)-(−)-Pindolol (CAS 26328-11-0) References
- The effect of ipsapirone and S(-)-pindolol on dopamine release in rat striatum and nucleus accumbens. | Ichikawa, J. and Meltzer, HY. 1999. Brain Res. 842: 445-51. PMID: 10526141
- Direct determination of pindolol enantiomers in human serum by column-switching LC-MS/MS using a phenylcarbamate-beta-cyclodextrin chiral column. | Motoyama, A., et al. 2002. J Pharm Biomed Anal. 28: 97-106. PMID: 11861113
- Enantioselectivity in the steady-state pharmacokinetics and transplacental distribution of pindolol at delivery in pregnancy-induced hypertension. | Gonçalves, PV., et al. 2002. Chirality. 14: 683-7. PMID: 12125040
- Enantiomeric separation and quantification of pindolol in human plasma by chiral liquid chromatography/tandem mass spectrometry using staggered injection with a CTC Trio Valve system. | Wang, H. and Shen, Z. 2006. Rapid Commun Mass Spectrom. 20: 291-7. PMID: 16345128
- Determination of pindolol enantiomers in amniotic fluid and breast milk by high-performance liquid chromatography: applications to pharmacokinetics in pregnant and lactating women. | Gonçalves, PV., et al. 2007. J Chromatogr B Analyt Technol Biomed Life Sci. 852: 640-5. PMID: 17307403
- Simultaneous enantiomeric determination of propranolol, metoprolol, pindolol, and atenolol in natural waters by HPLC on new polysaccharide-based stationary phase using a highly selective molecularly imprinted polymer extraction. | Morante-Zarcero, S. and Sierra, I. 2012. Chirality. 24: 860-6. PMID: 22778012
- Beta 1- and beta 2-adrenoceptor affinity and stimulatory effects of (S)-pindolol and iodinated (S)-pindolol. | Abrahamsson, T. and Nerme, V. 1987. Pharmacol Toxicol. 60: 120-4. PMID: 2883645
- Drug-induced penile erections in rats: indications of serotonin1B receptor mediation. | Berendsen, HH. and Broekkamp, CL. 1987. Eur J Pharmacol. 135: 279-87. PMID: 3495447
- Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of beta-adrenoceptor subtypes in the dissociation between blockade and stimulation. | Walter, M., et al. 1984. Naunyn Schmiedebergs Arch Pharmacol. 327: 159-75. PMID: 6092972
- High-performance liquid chromatographic analysis of pindolol enantiomers in human serum and urine using a reversed-phase cellulose-based chiral column. | Zhang, H., et al. 1995. J Chromatogr B Biomed Appl. 668: 309-13. PMID: 7581866
- 5-hydroxytryptamine1A receptor-mediated increases in receptor expression and activation of nuclear factor-kappaB in transfected Chinese hamster ovary cells. | Cowen, DS., et al. 1997. Mol Pharmacol. 52: 221-6. PMID: 9271344
- 5HT1A receptor antagonists enhance the functional activity of fluoxetine in a mouse model of feeding. | Li, DL., et al. 1998. Brain Res. 781: 121-8. PMID: 9507085
- Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors. | Perez, M., et al. 1998. Bioorg Med Chem Lett. 8: 3423-8. PMID: 9873746
Inhibitor of:
beta1-AR, SR-1A, and SR-1B.Activator of:
beta3-AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-(−)-Pindolol, 10 mg | sc-203688 | 10 mg | $210.00 | |||
| US: Only available in the US | ||||||
(S)-(−)-Pindolol, 50 mg | sc-203688A | 50 mg | $865.00 | |||
| US: Only available in the US | ||||||