Molecular structure of S-Phenylmercapturic Acid, CAS Number: 4775-80-8
S-Phenylmercapturic Acid (CAS 4775-80-8)
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Alternate Names:
N-Acetyl-S-phenyl-L-cysteine; N-Acetyl-3-(phenylthio)alanine, NSC 17197
Application:
S-Phenylmercapturic Acid is An important metabolite of Benzene.
CAS Number:
4775-80-8
Molecular Weight:
239.29
Molecular Formula:
C11H13NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
S-Phenylmercapturic Acid is an important metabolite of Benzene. S-Phenylmercapturic acid can serve as a biomarker and can be detected using various analytical methods such as GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS, or immunoassay. It is utilized to measure the concentration of guanine nucleotide-binding (GMP) in urine, providing a sensitive and specific test. The concentration of GMP is determined by plotting the fluorescence intensity of s-phenylmercapturic acid against GMP concentration, establishing a linear calibration curve. Its use as a biomarker has been validated through matrix effect techniques and solid phase microextraction, followed by dispersive solid phase extraction on a column with a fluorescence detector.
S-Phenylmercapturic Acid (CAS 4775-80-8) References
- Determination of urinary S-phenylmercapturic acid by liquid chromatography-tandem mass spectrometry. | Pieri, M., et al. 2003. J Chromatogr B Analyt Technol Biomed Life Sci. 795: 347-54. PMID: 14522039
- The use of S-phenylmercapturic acid as a biomarker in molecular epidemiology studies of benzene. | Farmer, PB., et al. 2005. Chem Biol Interact. 153-154: 97-102. PMID: 15935804
- Determination of S-phenylmercapturic acid in human urine using an automated sample extraction and fast liquid chromatography-tandem mass spectrometric method. | Li, Y., et al. 2006. Biomed Chromatogr. 20: 597-604. PMID: 16779771
- Enrichment and properties of urinary pre-S-phenylmercapturic acid (pre-SPMA). | Sterz, K., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 2502-5. PMID: 19762294
- S-phenylmercapturic acid (S-PMA) levels in urine as an indicator of exposure to benzene in the Kinshasa population. | Tuakuila, J. 2013. Int J Hyg Environ Health. 216: 494-8. PMID: 23619091
- Immunoenrichment of urinary S-phenylmercapturic acid. | Lathan Ball Alan S W Right Nico J van Sittert And Paulaston,. 1997. Biomarkers. 2: 29-33. PMID: 23899152
- An efficient analytical method for determination of S-phenylmercapturic acid in urine by HPLC fluorimetric detector to assessing benzene exposure. | Mendes, MPR., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1063: 136-140. PMID: 28863335
- New fully automated gas chromatographic analysis of urinary S-phenylmercapturic acid in isotopic dilution using negative chemical ionization with isobutane as reagent gas. | Dugheri, S., et al. 2020. J Mass Spectrom. 55: e4481. PMID: 31770470
- Biomonitoring of the benzene metabolite s-phenylmercapturic acid and the toluene metabolite s-benzylmercapturic acid in urine from firefighters. | Rosting, C. and Olsen, R. 2020. Toxicol Lett. 329: 20-25. PMID: 32380125
- Large Differences in Urinary Benzene Metabolite S-Phenylmercapturic Acid Quantitation: A Comparison of Five LC-MS-MS Methods. | Tevis, DS., et al. 2021. J Anal Toxicol. 45: 657-665. PMID: 33025019
- Magnetic molecularly imprinted polymers for extraction of S-phenylmercapturic acid from urine samples followed by high-performance liquid chromatography. | Ye, H., et al. 2021. J Mol Recognit. 34: e2930. PMID: 34432338
- Biological monitoring of exposure to benzene: a comparison between S-phenylmercapturic acid, trans,trans-muconic acid, and phenol. | Boogaard, PJ. and van Sittert, NJ. 1995. Occup Environ Med. 52: 611-20. PMID: 7550802
- Application of the urinary S-phenylmercapturic acid test as a biomarker for low levels of exposure to benzene in industry. | van Sittert, NJ., et al. 1993. Br J Ind Med. 50: 460-9. PMID: 8507599
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-Phenylmercapturic Acid, 25 mg | sc-212823 | 25 mg | $316.00 |