S-(p-Nitrobenzyl)-6-thioguanosine (CAS 13153-27-0)
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S-(p-Nitrobenzyl)-6-thioguanosine is a compound that has attention in biochemical research due to its utility as a photoaffinity label. It is particularly useful in studies aimed at identifying and characterizing nucleoside transporters, which play a role in cellular uptake of nucleosides and nucleoside-derived chemicals. By exploiting the photoreactive nitrobenzyl moiety, researchers can covalently attach S-(p-Nitrobenzyl)-6-thioguanosine to its binding sites, thereby capturing the interactions between the compound and the transporter proteins. This method facilitates the mapping of binding domains and elucidating the structure-function relationships of these transporters. Additionally, the thioguanosine component is structurally similar to naturally occurring guanosine, which makes S-(p-Nitrobenzyl)-6-thioguanosine a mimic that can competitively inhibit nucleoside transporters, providing insights into the regulatory mechanisms of nucleoside and nucleotide levels within cells.
S-(p-Nitrobenzyl)-6-thioguanosine (CAS 13153-27-0) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-(p-Nitrobenzyl)-6-thioguanosine, 10 mg | sc-296284 | 10 mg | $148.00 | |||
S-(p-Nitrobenzyl)-6-thioguanosine, 25 mg | sc-296284A | 25 mg | $362.00 |