(S)-(−)-Nicotine-d4 (CAS 284685-07-0)

(S)-(−)-Nicotine-d4 is a deuterated form of nicotine, where certain hydrogen atoms are replaced with deuterium, and is utilized in various research applications, particularly in the study of nicotine′s absorption, distribution, metabolism, and excretion. The addition of deuterium atoms allows for a detailed investigation of nicotine′s metabolic pathways by providing a distinguishable tracer that can be followed through different biological systems without altering the chemical′s biological activity. This compound serves as an internal standard in mass spectrometry, enabling researchers to more accurately quantify the presence of nicotine in samples by correcting for variations that occur during sample preparation and analysis. Moreover, (S)-(−)-Nicotine-d4 is employed in the field of neurobiology to explore the functioning of nicotinic acetylcholine receptors and their role in neurotransmission, which is fundamental for mapping the neural mechanisms affected by nicotine.