S-(N,N-Diethylcarbamoyl)glutathione (CAS 157723-51-8)

S-(N,N-Diethylcarbamoyl)glutathione is a derivative of glutathione, a tripeptide composed of glutamate, cysteine, and glycine, which plays a pivotal role in cellular antioxidant defense mechanisms and detoxification processes. This particular compound is modified by the addition of an N,N-diethylcarbamoyl group to the thiol group of cysteine in glutathione. This modification imparts unique chemical properties, influencing its reactivity and interaction with various biological molecules. In research applications, S-(N,N-Diethylcarbamoyl)glutathione is often utilized to study enzymatic activities related to glutathione metabolism, including glutathione S-transferases (GSTs), which are enzymes involved in the detoxification of endogenous and exogenous compounds by catalyzing the conjugation of glutathione to a wide variety of substrates. This compound helps in elucidating the mechanisms underlying the detoxification processes and the role of glutathione in cellular protection against oxidative stress and chemical toxicity. Its application in these areas contributes significantly to our understanding of cellular biochemistry and the molecular basis of detoxification pathways.