(S)-(−)-Thalidomide (CAS 841-67-8)
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(S)-(−)-Thalidomide is an optically active isomer of Thalidomide. Inhibits FGF-induced angiogenesis and replication of human immunodeficiency virus type 1. (S)-thalidomide is a 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has S-configuration at the chiral centre. It has a role as a teratogenic agent. It is an enantiomer of a (R)-thalidomide. It enhances TNF-α production induced by phorbol 12-myristate 13-acetate (TPA). Understanding how (S)-(−)-thalidomide interacts with biological targets, such as proteins or DNA, can provide valuable insights into the molecular mechanisms underlying its effects. This research can contribute to the broader knowledge of how small molecules influence cellular processes and lead to the discovery of new targets. The synthesis of pure enantiomers like (S)-(−)-thalidomide is a significant challenge in organic chemistry. Developing methods for the enantioselective synthesis or the resolution of racemic mixtures into their individual enantiomers is for producing compounds with the desired biological activity.
(S)-(−)-Thalidomide (CAS 841-67-8) References
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- Towards understanding the interaction of (S)-thalidomide with nucleobases. | Baranowska-Łączkowska, A., et al. 2020. Arch Biochem Biophys. 693: 108566. PMID: 32896516
- The structure of isolated thalidomide as reference for its chirality-dependent biological activity: a laser-ablation rotational study. | Blanco, S., et al. 2021. Phys Chem Chem Phys. 23: 13705-13713. PMID: 34128013
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- Evaluation of stability difference between asymmetric homochiral dimer in (S)-thalidomide crystal and symmetric heterochiral dimer in (RS)-thalidomide crystal | Toshiya Suzuki, Masahito Tanaka, Motoo Shiro, Norio Shibata, Tetsuya Osaka & Toru Asahi. 2010. Phase Transitions. 83: 223-234.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-(−)-Thalidomide, 10 mg | sc-208337 | 10 mg | $203.00 | |||
(S)-(−)-Thalidomide, 50 mg | sc-208337A | 50 mg | $681.00 |