Date published: 2026-4-25

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(S)-(−)-Methylsuccinic acid (CAS 2174-58-5)

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Alternate Names:
(S)-(−)-Pyrotartaric Acid
CAS Number:
2174-58-5
Purity:
≥98%
Molecular Weight:
132.11
Molecular Formula:
C5H8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(S)-(−)-Methylsuccinic acid finds diverse applications as a substrate in enzyme assays, a buffer in chromatography, and a reagent in organic synthesis. In the realm of metabolism, it serves as an intermediate for specific amino acids. The enzyme methylmalonyl-CoA mutase plays a role in transforming methylmalonyl-CoA into succinyl-CoA, with methylsuccinic acid being an integral part of this process. This metabolic conversion is an integral step within the citric acid cycle, a sequence of biochemical reactions that holds utmost significance in the generation of cellular energy.


(S)-(−)-Methylsuccinic acid (CAS 2174-58-5) References

  1. Preparation of open tubular molecule imprinted polymer capillary columns with various templates by a generalized procedure and their chiral and non-chiral separation performance in CEC.  |  Zaidi, SA., et al. 2010. Electrophoresis. 31: 1019-28. PMID: 20155740
  2. Open tubular molecular imprinted phases in chiral capillary electrochromatography.  |  Cheong, WJ. and Yang, SH. 2013. Methods Mol Biol. 970: 469-87. PMID: 23283797
  3. Molecular Basis for Converting (2S)-Methylsuccinyl-CoA Dehydrogenase into an Oxidase.  |  Burgener, S., et al. 2017. Molecules. 23: PMID: 29283425
  4. Characterization and engineering of branched short-chain dicarboxylate metabolism in Pseudomonas reveals resistance to fungal 2-hydroxyparaconate.  |  de Witt, J., et al. 2023. Metab Eng. 75: 205-216. PMID: 36581064
  5. A Reinvestigation of the Role of the Sorbic Acid Tail on the Antibacterial and Anti-Tuberculosis Properties of Moiramide B.  |  Kollmorgen, I., et al. 2023. ChemMedChem. e202200631. PMID: 36883965
  6. Recent applications and chiral separation development based on stationary phases in open tubular capillary electrochromatography (2019-2022).  |  Li, X., et al. 2023. J Pharm Anal. 13: 323-339. PMID: 37181297

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(S)-(−)-Methylsuccinic acid, 5 g

sc-255555
5 g
$297.00