Molecular structure of (S)-MCPG, CAS Number: 150145-89-4
(S)-MCPG (CAS 150145-89-4)
Alternate Names:
(+)-α-Methyl-4-carboxyphenylglycine; (+)-MCPG; S(+)-α-Amino-4-carboxy-α-methyl-benzeneacetic acid
Application:
(S)-MCPG is a non-selective group I/II mGluR antagonist
CAS Number:
150145-89-4
Purity:
≥97%
Molecular Weight:
209.2
Molecular Formula:
C10H11NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(S)-MCPG is an antagonist of the group I/II metabotropic glutamate receptors (mGluR) and is the active isomer of (RS)-MCPG (sc-202325) preparations. Perturbation of the group I/II mGluR (mGluR-1a, mGluR-2, mGluR-3, mGluR-5) by (S)-MCPG has been used to assess the function of mGluRs in spatial learning, demonstrating that a particular subset of spatial learning tasks are correlated with MCPG-sensitive mGluRs while NMDA receptors are shown to play an integral role in all spatial learning. (S)-MCPG is also described to block induction of long-term potentiation through interaction with the mGluRs.
(S)-MCPG (CAS 150145-89-4) References
- Group I metabotropic glutamate receptors mediate an inward current in rat substantia nigra dopamine neurons that is independent from calcium mobilization. | Guatteo, E., et al. 1999. J Neurophysiol. 82: 1974-81. PMID: 10515987
- Pharmacological agents acting at subtypes of metabotropic glutamate receptors. | Schoepp, DD., et al. 1999. Neuropharmacology. 38: 1431-76. PMID: 10530808
- Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro. | Thomas, LS., et al. 2000. Neuropharmacology. 39: 1554-66. PMID: 10854900
- Actions of Group I and Group II metabotropic glutamate receptor ligands on 5-hydroxytryptamine release in the rat cerebral cortex in vivo: differential roles in the regulation of central serotonergic neurotransmission. | Lee, JJ. and Croucher, MJ. 2003. Neuroscience. 117: 671-9. PMID: 12617971
- Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones. | Jane, DE., et al. 1993. Neuropharmacology. 32: 725-7. PMID: 7689710
- Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. | Watkins, J. and Collingridge, G. 1994. Trends Pharmacol Sci. 15: 333-42. PMID: 7992387
- Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors. | Kemp, M., et al. 1994. Eur J Pharmacol. 266: 187-92. PMID: 8157072
- Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1 alpha and mGluR5a subtypes. | Kingston, AE., et al. 1995. Neuropharmacology. 34: 887-94. PMID: 8532170
- Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. | Sekiyama, N., et al. 1996. Br J Pharmacol. 117: 1493-503. PMID: 8730745
- Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. | Bordi, F., et al. 1996. Neuropharmacology. 35: 1557-65. PMID: 9025103
- (R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivo. | Martin, SJ. and Morris, RG. 1997. Neuropharmacology. 36: 1339-54. PMID: 9423922
- (+)-MCPG blocks induction of LTP in CA1 of rat hippocampus via agonist action at an mGluR group II receptor. | Breakwell, NA., et al. 1998. J Neurophysiol. 79: 1270-6. PMID: 9497408
- Inhibition of group I metabotropic glutamate receptors blocks spatial learning in rats. | Balschun, D. and Wetzel, W. 1998. Neurosci Lett. 249: 41-4. PMID: 9672384
Inhibitor of:
EAAT1, mGluR-1a, mGluR-2, mGluR-3, mGluR-5, mGLuR-8, and V1RB1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-MCPG, 5 mg | sc-202329 | 5 mg | $146.00 | |||
(S)-MCPG, 25 mg | sc-202329A | 25 mg | $964.00 |