Molecular structure of (S)-Ketoprofen, CAS Number: 22161-81-5
(S)-Ketoprofen (CAS 22161-81-5)
Application:
(S)-Ketoprofen is an inhibitor of TXB2 generation and of Cox
CAS Number:
22161-81-5
Purity:
≥98%
Molecular Weight:
254.28
Molecular Formula:
C16H14O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
(S)-Ketoprofen, the active form of ketoprofen, has been found to contain antiplatelet effects via inhibition of platelet thromboxane B2 (TXB2) generation. Studies show that this compound is also a potent inhibitor of prostaglandin F2 alpha production. Additional experiments suggest that (S)-Ketoprofen contains antinociceptive properties which are involved in serotoninergic mechanism via both 5-HT(3) receptors located at spinal level and supraspinal 5-HT(1)/5-HT(2)/5-HT(7) receptors. (S)-Ketoprofen inhibits Cox (cyclooxygenase). (S)-Ketoprofen is an inhibitor of Cox-1 and Cox-2.
(S)-Ketoprofen (CAS 22161-81-5) References
- Influence of (S)-ketoprofen and fluoride on caries in rats. | Bowen, WH., et al. 2000. Oral Dis. 6: 12-4. PMID: 10673782
- Evidence for a central mechanism of action of S-(+)-ketoprofen. | Díaz-Reval, MI., et al. 2004. Eur J Pharmacol. 483: 241-8. PMID: 14729113
- Enantioselective pharmacodynamics of the nonsteroidal antiinflammatory drug ketoprofen: in vitro inhibition of human platelet cyclooxygenase activity. | Hayball, PJ., et al. 1992. Chirality. 4: 484-7. PMID: 1476858
- Ketoprofen in piglets: enantioselective pharmacokinetics, pharmacodynamics and PK/PD modelling. | Fosse, TK., et al. 2011. J Vet Pharmacol Ther. 34: 338-49. PMID: 20950352
- Chiral inversion of R(-) to S(+) ketoprofen in pigs. | Neirinckx, E., et al. 2011. Vet J. 190: 290-292. PMID: 22108189
- Crystal structure and characterization of esterase Est25 mutants reveal improved enantioselectivity toward (S)-ketoprofen ethyl ester. | Kim, J., et al. 2017. Appl Microbiol Biotechnol. 101: 2333-2342. PMID: 27915377
- Intestinal Ulcerogenic Effect of S(+)-Ketoprofen in the Rat. | Cabré, F., et al. 1998. J Clin Pharmacol. 38: 27S-32S. PMID: 29023865
- Lipase Assisted (S)-Ketoprofen Resolution from Commercially Available Racemic Mixture. | Estrada-Valenzuela, D., et al. 2021. Pharmaceuticals (Basel). 14: PMID: 34681221
- Stereoselectivity of Interaction of Nonsteroidal Anti-Inflammatory Drug S-Ketoprofen with L/D-Tryptophan in Phospholipid Membranes. | Mastova, AV., et al. 2022. Membranes (Basel). 12: PMID: 35629787
- Stereoselective inhibition of rat brain cyclooxygenase by dexketoprofen. | Carabaza, A., et al. 1997. Chirality. 9: 281-5. PMID: 9176993
- Enantiospecific inhibition of ligature-induced periodontitis in beagles with topical (S)-ketoprofen. | Paquette, DW., et al. 1997. J Clin Periodontol. 24: 521-8. PMID: 9266337
- Analgesic, antiinflammatory, and antipyretic effects of S(+)-ketoprofen in vivo. | Cabré, F., et al. 1998. J Clin Pharmacol. 38: 3S-10S. PMID: 9882076
- Bioavailability of S(+)-ketoprofen after oral administration of different mixtures of ketoprofen enantiomers to dogs. | García, ML., et al. 1998. J Clin Pharmacol. 38: 22S-26S. PMID: 9882078
Inhibitor of:
Cox-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-Ketoprofen, 1 g | sc-200624 | 1 g | $118.00 |