(S)-Ganciclovir-5′-triphosphate Lithium Salt (CAS 86761-38-8 (non-salt))
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(S)-Ganciclovir-5′-triphosphate Lithium Salt is a nucleoside analogue of guanosine. In various laboratory applications, (S)-Ganciclovir-5′-triphosphate Lithium Salt finds utility. Its use in the laboratory involves investigating CMV infection effects on cells and tissues, as well as exploring the mechanisms of action of other antiviral drugs. After metabolized, (S)-Ganciclovir-5′-triphosphate Lithium Salt transforms into ganciclovir monophosphate and ganciclovir diphosphate. Ganciclovir diphosphate is then integrated into the DNA of CMV-infected cells, acting as a chain terminator that hinders viral replication. Research has demonstrated its effectiveness in impeding CMV replication, inhibiting the release of infectious particles, and reducing the production of viral proteins. Additionally, it has been observed to mitigate the cytopathic effects of CMV, such as cell death and lysis.
(S)-Ganciclovir-5′-triphosphate Lithium Salt (CAS 86761-38-8 (non-salt)) References
- Liquid chromatography tandem mass spectrometry quantitation of intracellular concentrations of ganciclovir and its phosphorylated forms. | Billat, PA., et al. 2015. Anal Bioanal Chem. 407: 3449-56. PMID: 25701963
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-Ganciclovir-5′-triphosphate Lithium Salt, 1 µmol | sc-363645 | 1 µmol | $321.00 | |||
(S)-Ganciclovir-5′-triphosphate Lithium Salt, 5 µmol | sc-363645A | 5 µmol | $1377.00 |