Molecular structure of S-Ethylisothiourea HBr, CAS Number: 1071-37-0
S-Ethylisothiourea HBr (CAS 1071-37-0)
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Alternate Names:
S-Ethylisothiourea hydrobromide
Application:
S-Ethylisothiourea HBr is a highly potent L-Arginine competitive inhibitor of NOS2
CAS Number:
1071-37-0
Purity:
≥97%
Molecular Weight:
185.09
Molecular Formula:
C3H8N2S•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
S-Ethylisothiourea strongly competes with L-arginine to inhibit NOS2. S-Ethylisothiourea has been observed to specifically inhibit NOS2 activity in J774 mouse macrophages and possesses the potential to be an inflammatory and autoimmune disease therapeutic. S-Ethylisothiourea has also shown to reduce endogenous ISGylation and synthetic derivatives of S-Ethylisothiourea have possible hypertensive effects.
S-Ethylisothiourea HBr (CAS 1071-37-0) References
- Contractions to histamine in pulmonary and mesenteric arteries from endotoxemic rabbits: modulation by vascular expressions of inducible nitric-oxide synthase and histamine H1-receptors. | Matsuda, N., et al. 2003. J Pharmacol Exp Ther. 307: 175-81. PMID: 12954799
- Protection against MPP+ neurotoxicity in cerebellar granule cells by antioxidants. | González-Polo, RA., et al. 2004. Cell Biol Int. 28: 373-80. PMID: 15193280
- Calcium/calmodulin-dependent nitric oxide synthase activity in the CNS of Aplysia californica: biochemical characterization and link to cGMP pathways. | Bodnárová, M., et al. 2005. J Inorg Biochem. 99: 922-8. PMID: 15811509
- Nitric oxide synthase inhibitor (MTR-105) during open-heart surgery. A pilot double-blind placebo-controlled study of hemodynamic effects and safety. | Sasson, L., et al. 2008. Cardiology. 111: 181-7. PMID: 18434722
- Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation. | Okumura, F., et al. 2008. J Biol Chem. 283: 24484-8. PMID: 18606809
- Short-term regulation of tumor necrosis factor-alpha-induced lipolysis in 3T3-L1 adipocytes is mediated through the inducible nitric oxide synthase/nitric oxide-dependent pathway. | Lien, CC., et al. 2009. Endocrinology. 150: 4892-900. PMID: 19819972
- Depletion of circulating blood NOS3 increases severity of myocardial infarction and left ventricular dysfunction. | Merx, MW., et al. 2014. Basic Res Cardiol. 109: 398. PMID: 24346018
- Small change for big improvement in the preparation of the key intermediate N 1, N 3-disubstituted 1,3,5-triazone of ensitrelvir. | Hu, W., et al. 2023. RSC Adv. 13: 3688-3693. PMID: 36756552
- Novel potent and selective inhibitors of inducible nitric oxide synthase. | Nakane, M., et al. 1995. Mol Pharmacol. 47: 831-4. PMID: 7536889
Inhibitor of:
Enzyme, NOS1, NOS2, and NOS3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-Ethylisothiourea HBr, 50 mg | sc-200351 | 50 mg | $20.00 |