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S-Ethyl N-Phenylisothiourea is a potent inhibitor of the human neuronal, constitutive, and inducible isoforms of nitric oxide synthetase (NOS). It demonstrates competitive binding with L-Arginine.
1. Shearer, B G., et al., 1997. Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. Journal of medicinal chemistry. 40(12): 1901-5. PMID: 9191968
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