Molecular structure of (S)-ESBA hydrochloride
(S)-ESBA hydrochloride
See product citations (1)
Application:
(S)-ESBA hydrochloride is a mouse and rat KAT II inhibitor
Purity:
≥98%
Molecular Weight:
321.78
Molecular Formula:
C12H15NO5S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
(S)-ESBA HCl is a compound that functions as a selective and potent inhibitor of a enzyme. It acts by binding to the active site of the enzyme, preventing its normal substrate from binding and inhibiting its catalytic activity. (S)-ESBA HCl targets the enzyme′s active site, disrupting its function at the molecular level. (S)-ESBA HCl interferes with the enzyme′s ability to carry out its normal cellular processes. (S)-ESBA HCl involves disrupting the enzyme′s normal function without affecting other cellular processes, allowing for precise investigation of the enzyme′s role in cellular function.
(S)-ESBA hydrochloride References
- Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor. | Pellicciari, R., et al. 2006. ChemMedChem. 1: 528-31. PMID: 16892388
- Toxoplasma gondii and schizophrenia: linkage through astrocyte-derived kynurenic acid? | Schwarcz, R. and Hunter, CA. 2007. Schizophr Bull. 33: 652-3. PMID: 17434932
- Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA. | Pellicciari, R., et al. 2008. ChemMedChem. 3: 1199-202. PMID: 18537204
- Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis. | Rossi, F., et al. 2008. Curr Opin Struct Biol. 18: 748-55. PMID: 18950711
- Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. | Amori, L., et al. 2009. Neuroscience. 159: 196-203. PMID: 19138730
- Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release. | Zmarowski, A., et al. 2009. Eur J Neurosci. 29: 529-38. PMID: 19187269
- Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry. | Konradsson-Geuken, A., et al. 2010. Neuroscience. 169: 1848-59. PMID: 20600676
Inhibitor of:
KAT II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-ESBA hydrochloride, 1 mg | sc-222282 | 1 mg | $59.00 | |||
(S)-ESBA hydrochloride, 5 mg | sc-222282A | 5 mg | $173.00 |