Molecular structure of (S)-(+)-Dimethindene maleate, CAS Number: 121367-05-3
(S)-(+)-Dimethindene maleate (CAS 121367-05-3)
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Alternate Names:
N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate
Application:
(S)-(+)-Dimethindene maleate is a subtype-selective mAChR M2 antagonist and histamine H1 receptor antagonist
CAS Number:
121367-05-3
Purity:
≥99%
Molecular Weight:
408.5
Molecular Formula:
C20H24N2•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(S)-(+)-Dimethindene maleate is a chemical compound that belongs to the family of antihistamines. It is an enantiomer that is a subtype-selective mAChR M2, mAChR M1, mAChR M3, and mAChR M4 antagonist as well as a histamine H1 receptor antagonist. By blocking the histamine H1 receptor, (S)-(+)-Dimethindene maleate reduces the release of inflammatory mediators, such as prostaglandins and leukotrienes. This leads to a decrease in inflammation, swelling, and itching. This compound has been used to investigate the role of histamine in various physiological processes, including inflammation, immune response, and allergic reactions.
(S)-(+)-Dimethindene maleate (CAS 121367-05-3) References
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- Etv5 safeguards trophoblast stem cells differentiation from mouse EPSCs by regulating fibroblast growth factor receptor 2. | Zhu, K., et al. 2020. Mol Biol Rep. 47: 9259-9269. PMID: 33159233
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- Chemically defined and xeno-free culture condition for human extended pluripotent stem cells. | Liu, B., et al. 2021. Nat Commun. 12: 3017. PMID: 34021145
- Strategy to Establish Embryo-Derived Pluripotent Stem Cells in Cattle. | Kim, D. and Roh, S. 2021. Int J Mol Sci. 22: PMID: 34065074
- Derivation of feeder-free human extended pluripotent stem cells. | Zheng, R., et al. 2021. Stem Cell Reports. 16: 1686-1696. PMID: 34214484
- Generation of human blastocyst-like structures from pluripotent stem cells. | Fan, Y., et al. 2021. Cell Discov. 7: 81. PMID: 34489415
- Derivation of Porcine Extra-Embryonic Endoderm Cell Lines Reveals Distinct Signaling Pathway and Multipotency States. | Zhang, ML., et al. 2021. Int J Mol Sci. 22: PMID: 34884722
- dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region. | Levy, S., et al. 2022. Cell Rep. 38: 110457. PMID: 35235780
- Porcine Pluripotent Stem Cells Established from LCDM Medium with Characteristics Differ from Human and Mouse Extended Pluripotent Stem Cells. | Yu, Z., et al. 2022. Stem Cells. 40: 751-762. PMID: 35583192
- The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. | Pfaff, O., et al. 1995. Eur J Pharmacol. 286: 229-40. PMID: 8608784
Inhibitor of:
Histamine H1 Receptor, mAChR M1, mAChR M2, mAChR M3, and mAChR M4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-(+)-Dimethindene maleate, 10 mg | sc-361329 | 10 mg | $235.00 | |||
| US: Only available in the US | ||||||
(S)-(+)-Dimethindene maleate, 50 mg | sc-361329A | 50 mg | $960.00 | |||
| US: Only available in the US | ||||||