Molecular structure of (S)-CPW 399, CAS Number: 389888-02-2
(S)-CPW 399 (CAS 389888-02-2)
Alternate Names:
(S)-α-Amino-2,3,4,5,6,7-hexahydro-2,4-dioxo-1H-cyclopentapyrimidine-1-propanoic acid
Application:
(S)-CPW 399 is a subtype-selective weakly desensitising AMPA agonist
CAS Number:
389888-02-2
Molecular Weight:
239.23
Molecular Formula:
C10H13N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(S)-CPW 399 is a subtype-selective weakly desensitising AMPA agonist. At GluR1 and GluR2 subunit-containing AMPA receptors, exhibits potent agonist activity. Excitotoxic in vitro. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
(S)-CPW 399 (CAS 389888-02-2) References
- Inherent desensitisation-preventing properties of a novel, subtype-selective AMPA receptor agonist, (S)-CPW 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells. | Sinclair, C., et al. 2003. Neurochem Int. 42: 499-510. PMID: 12547649
- Inhibition of presynaptic release-facilitatory kainate autoreceptors by extracellular cyclic GMP. | Cervetto, C., et al. 2010. J Pharmacol Exp Ther. 332: 210-9. PMID: 19794031
- Calcium-permeable AMPA receptors trigger vesicular glutamate release from Bergmann gliosomes. | Cervetto, C., et al. 2015. Neuropharmacology. 99: 396-407. PMID: 26260232
Activator of:
GluR-1, and GluR-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-CPW 399, 10 mg | sc-203690 | 10 mg | $300.00 | |||
(S)-CPW 399, 50 mg | sc-203690A | 50 mg | $865.00 |