Molecular structure of (S)-Citalopram N-Oxide, CAS Number: 917482-45-2
(S)-Citalopram N-Oxide (CAS 917482-45-2)
Alternate Names:
(S)-1-[3-(Dimethyloxidoamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro -5-isobenzofurancarbonitrile
Application:
(S)-Citalopram N-Oxide is a derivative of Citalopram and a potential 5-HT selective inhibitor
CAS Number:
917482-45-2
Molecular Weight:
340.39
Molecular Formula:
C20H21FN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(S)-Citalopram N-Oxide is a derivative of Citalopram (sc-201123). Citalopram is a selective inhibitor of the 5-hydroxytryptamine transporter (serotonin) and therefore is a potent and selective serotonin reuptake inhibitor. Additional studies indicate that Citalopram may be a weak, allosteric modulator of serotonin in a cross-species chimeric study. Studies also indicate that Citalopram is useful for studying gene expression patterns in circulating lymphocytes. In zebrafish, Citalopram is noted to reduce the frequency of NMDA-induced locomotor rhythm involved in swimming behavor.
(S)-Citalopram N-Oxide (CAS 917482-45-2) References
- Plasma membrane monoamine transporters: structure, regulation and function. | Torres, GE., et al. 2003. Nat Rev Neurosci. 4: 13-25. PMID: 12511858
- The effect of citalopram on gene expression profile of Alzheimer lymphocytes. | Palotás, A., et al. 2004. Neurochem Res. 29: 1563-70. PMID: 15260135
- Dissection of an allosteric mechanism on the serotonin transporter: a cross-species study. | Neubauer, HA., et al. 2006. Mol Pharmacol. 69: 1242-50. PMID: 16434615
- Serotonergic modulation of locomotion in zebrafish: endogenous release and synaptic mechanisms. | Gabriel, JP., et al. 2009. J Neurosci. 29: 10387-95. PMID: 19692613
- Identification of a novel CYP2C19-mediated metabolic pathway of S-citalopram in vitro. | Rudberg, I., et al. 2009. Drug Metab Dispos. 37: 2340-8. PMID: 19773541
- PharmGKB summary: citalopram pharmacokinetics pathway. | Sangkuhl, K., et al. 2011. Pharmacogenet Genomics. 21: 769-72. PMID: 21546862
- Assessing the safety of medications during pregnancy using multi-omics and a neuronal differentiation model of early human neurodevelopment | Spildrejorde, Mari. 2023.
- The Influence of CYP2C19 Gene Polymorphism on Selective Serotonin Reuptake Inhibitors In Patients with Major Depressive Disorder: A Pharmacogenetic Prospecting Approach | Urbaningrum, Lestari Mahardika, et al. 2024. Journal of Biomedicine and Translational Research. 10.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-Citalopram N-Oxide, 1 mg | sc-212881 | 1 mg | $340.00 |