Molecular structure of (S)-Baclofen
(S)-Baclofen (CAS 66514-99-6)
Alternate Names:
d-Baclofen; S(+)-Baclofen
Application:
(S)-Baclofen is a specific GABA-B receptor agonist
CAS Number:
66514-99-6
Molecular Weight:
213.66
Molecular Formula:
C10H12ClNO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(S)-Baclofen is a specific GABA-B receptor agonist.
(S)-Baclofen (CAS 66514-99-6) References
- Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures. | Mandema, JW., et al. 1992. J Pharmacol Exp Ther. 261: 88-95. PMID: 1560387
- Genomic and functional conservation of sedative-hypnotic targets in the zebrafish. | Renier, C., et al. 2007. Pharmacogenet Genomics. 17: 237-53. PMID: 17496723
- The stimulation of GABA(B) receptors increases serotonin release in the rat suprachiasmatic area. | François-Bellan, AM., et al. 1987. Neurochem Int. 11: 55-62. PMID: 20501142
- Microwave-assisted synthesis and reversed-phase high-performance liquid chromatographic separation of diastereomers of (R,S)-baclofen using ten chiral derivatizing reagents designed from trichloro-s-triazine. | Bhushan, R. and Dixit, S. 2010. J Chromatogr A. 1217: 6382-7. PMID: 20817188
- GABAergic neural activity involved in salicylate-induced auditory cortex gain enhancement. | Lu, J., et al. 2011. Neuroscience. 189: 187-98. PMID: 21664433
- Metabolic and Pharmacokinetic Differentiation of STX209 and Racemic Baclofen in Humans. | Sanchez-Ponce, R., et al. 2012. Metabolites. 2: 596-613. PMID: 24957649
- GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism. | Silverman, JL., et al. 2015. Neuropsychopharmacology. 40: 2228-39. PMID: 25754761
- One-Pot Synthesis of (S)-Baclofen via Aldol Condensation of Acetaldehyde with Diphenylprolinol Silyl Ether Mediated Asymmetric Michael Reaction as a Key Step. | Hayashi, Y., et al. 2016. Org Lett. 18: 4-7. PMID: 26636719
- Efficient Synthesis of β-Aryl-γ-lactams and Their Resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen. | Montoya-Balbás, IJ., et al. 2015. Molecules. 20: 22028-43. PMID: 26690390
- R(-)-baclofen: focal epilepsy after intracortical administration in the rat. | Van Rijn, CM., et al. 1987. Epilepsy Res. 1: 321-7. PMID: 3143555
- Enantioselective Synthesis of γ-Functionalized Cyclopentenones and Δ-Functionalized Cycloheptenones Utilizing a Redox-Relay Heck Strategy. | Yuan, Q., et al. 2020. Adv Synth Catal. 362: 326-330. PMID: 33447174
- GABAB receptor-mediated inhibition of serotonin release in the rat brain. | Schlicker, E., et al. 1984. Naunyn Schmiedebergs Arch Pharmacol. 326: 99-105. PMID: 6206406
- GABAB receptor-mediated inhibition of tetrodotoxin-resistant GABA release in rodent hippocampal CA1 pyramidal cells. | Jarolimek, W. and Misgeld, U. 1997. J Neurosci. 17: 1025-32. PMID: 8994057
Activator of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-Baclofen, 10 mg | sc-396081 | 10 mg | $290.00 | |||
(S)-Baclofen, 25 mg | sc-396081A | 25 mg | $540.00 | |||
(S)-Baclofen, 50 mg | sc-396081B | 50 mg | $970.00 | |||
(S)-Baclofen, 100 mg | sc-396081C | 100 mg | $2000.00 |