S-antigen Antibody (PFS-3): sc-52210
- S-antigen Antibody (PFS-3) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a synthetic peptide corresponding to the S-antigen of Plasmodium falciparum origin
- recommended for detection of S-antigen of P. falciparum of Plasmodium falciparum origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for S-antigen Antibody (PFS-3). This work is in progress.
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S-antigen Antibody (PFS-3) is a mouse monoclonal IgG1 antibody that detects S-antigen of Plasmodium falciparum by western blotting (WB). S-antigen is a crucial protein in the life cycle of the malaria-causing protozoan parasite, Plasmodium falciparum, and plays a significant role in the parasite′s ability to evade the host′s immune response. Located in the parasitophorous vacuole of the mature asexual intraerythrocytic parasite, S-antigen exhibits considerable antigenic diversity, which poses challenges for vaccine development. The S-antigen gene comprises multiple alleles originating from the same chromosomal site, with each allele featuring a central region of tandemly arranged, nearly identical peptides that are specific to that allele. This structural characteristic allows for the identification of distinct serotypes based on the repeat region, while the flanking non-repetitive sequences define four different S-antigen families, each exhibiting significant variation, particularly in the C-terminal-flanking region. The ability to differentiate between these families is essential for understanding the immune response to malaria and developing effective therapeutic strategies. S-antigen monoclonal antibody (PFS-3) is an invaluable tool for researchers studying the complexities of malaria pathogenesis and the immune evasion mechanisms employed by Plasmodium falciparum.
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S-antigen Antibody (PFS-3) References:
- Human retinal S-antigen: T cell epitope mapping in posterior uveitis patients. | Rai, G., et al. 2001. Exp Mol Pathol. 70: 140-5. PMID: 11263956
- A 48-kDa, S-antigen-like phosphoprotein in yeast DNA-replicative complex preparations. | Jeansonne, NE., et al. 1991. J Biol Chem. 266: 14675-80. PMID: 1860866
- The mouse S-antigen gene. Comparison with human and Drosophila. | Tsuda, M., et al. 1991. Eur J Biochem. 200: 95-101. PMID: 1879432
- S-antigen and rod-opsin immunoreactions in midline brain neoplasms of transgenic mice: similarities to pineal cell tumors and certain medulloblastomas in man. | Korf, HW., et al. 1990. J Neuropathol Exp Neurol. 49: 424-37. PMID: 2141872
- S-antigen. Identification of human T-cell lymphocyte proliferation sites. | Vrabec, TR., et al. 1990. Arch Ophthalmol. 108: 1470-3. PMID: 2222280
- Photoreceptor cell-specific localization of S-antigen in retina. | Broekhuyse, RM. and Winkens, HJ. 1985. Curr Eye Res. 4: 703-6. PMID: 2411473
- S-antigen-specific rat T cell lines recognize peptide fragments of S-antigen and mediate experimental autoimmune uveoretinitis and pinealitis. | Gregerson, DS., et al. 1986. J Immunol. 136: 2875-82. PMID: 2420873
- Immunoreactive S-antigen in cerebrospinal fluid: a marker of pineal parenchymal tumors? | Korf, HW., et al. 1989. J Neurosurg. 70: 682-7. PMID: 2709107
- Ultrastructural pathology of S-antigen uveoretinitis. | Forrester, JV., et al. 1985. Invest Ophthalmol Vis Sci. 26: 1281-92. PMID: 4030255
- S antigen-induced experimental autoimmune uveo-retinitis in rats. | de Kozak, Y., et al. 1981. Curr Eye Res. 1: 327-37. PMID: 6975701
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-antigen Antibody (PFS-3) | sc-52210 | 100 µg/ml | $322.00 |