S-antigen Antibody (PFS-2): sc-52209
- S-antigen Antibody (PFS-2) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a synthetic peptide corresponding to the S-antigen of Plasmodium falciparum origin
- recommended for detection of S-antigen of P. falciparum of Plasmodium falciparum origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for S-antigen Antibody (PFS-2). This work is in progress.
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S-antigen Antibody (PFS-2) is a mouse monoclonal IgG1 antibody that detects S-antigen of Plasmodium falciparum by western blotting (WB). S-antigen is a crucial protein in the life cycle of the malaria-causing protozoan parasite, Plasmodium falciparum, and plays a significant role in the parasite′s ability to evade the host′s immune response. Located in the parasitophorous vacuole of the mature asexual intraerythrocytic parasite, S-antigen exhibits considerable antigenic diversity, which poses challenges for vaccine development. The S-antigen gene comprises multiple alleles originating from the same chromosomal site, with each allele featuring a central region of tandemly arranged, nearly identical peptides that are specific to that allele. This structural characteristic allows for the identification of distinct serotypes based on the repeat region, while the flanking non-repetitive sequences define four different S-antigen families, each exhibiting significant variation, particularly in the C-terminal-flanking region. The ability to differentiate between these families is essential for understanding the immune response to malaria and developing effective therapeutic strategies. S-antigen monoclonal antibody (PFS-2) is an invaluable tool for researchers studying the complexities of malaria pathogenesis and the immune evasion mechanisms employed by Plasmodium falciparum.
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S-antigen Antibody (PFS-2) References:
- Cytokine induction by immunomodulatory epitopes in S-antigen and tumor necrosis factor alpha. | Stiemer, RH., et al. 1992. Curr Eye Res. 11 Suppl: 197-202. PMID: 1385043
- S-antigen: preparation and characterization of site-specific monoclonal antibodies. | Donoso, LA., et al. 1990. Curr Eye Res. 9: 343-55. PMID: 1692780
- S-antigen in non ocular tissues. | Faure, JP. and Mirshahi, M. 1990. Curr Eye Res. 9 Suppl: 163-7. PMID: 2200642
- A novel c.166A>T (p.Thr56Ser) mutation in GYPB*S accounting for unusual S antigen expression. | Suzuki, Y., et al. 2019. Vox Sang. 114: 171-173. PMID: 30523644
- Characterization of GYP*Mur and novel GYP*Bun-like hybrids in Thai blood donors reveals a qualitatively altered s antigen. | Jongruamklang, P., et al. 2020. Vox Sang. 115: 472-477. PMID: 32201961
- S-antigen immunoreactivity in trilateral retinoblastoma. | Donoso, LA., et al. 1987. Am J Ophthalmol. 103: 57-62. PMID: 3541632
- The study of variant s antigen expression revealing a novel c.160C>T (p.Arg54Cys) variant on GYPB*s allele associated with partial s phenotype. | Wei, L., et al. 2024. Transfusion. 64: 380-387. PMID: 38158881
- Development of a quantitative ELISA for SARS-CoV-2 vaccine candidate, NDV-HXP-S, with CpG 1018® adjuvant. | Estrada, M., et al. 2024. Hum Vaccin Immunother. 20: 2315709. PMID: 38372198
- S-antigen in the developing retina and pineal gland: a monoclonal antibody study. | Donoso, LA., et al. 1985. Invest Ophthalmol Vis Sci. 26: 561-7. PMID: 3884540
- Human retinal S-antigen. Isolation, purification, and characterization. | Beneski, DA., et al. 1984. Invest Ophthalmol Vis Sci. 25: 686-90. PMID: 6724838
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-antigen Antibody (PFS-2) | sc-52209 | 100 µg/ml | $322.00 |