(S)-Anabasine (CAS 494-52-0)

(S)-Anabasine, a chiral alkaloid found in the Nicotiana genus, predominantly found in tobacco and related plants, exhibits a fascinating profile as a ligand with a high affinity for nicotinic acetylcholine receptors (nAChRs). This compound′s stereochemistry, denoted by the (S)-prefix, plays a role in its interaction with nAChRs, facilitating research into the structural and functional dynamics of these receptor systems. As a structural analog of nicotine, (S)-Anabasine serves as a pivotal tool in neurobiological studies, aiding in the elucidation of the mechanisms underlying nAChR-mediated signal transduction pathways. Its ability to bind selectively to various nAChR subtypes has propelled its use in dissecting the roles of these receptors in neurophysiological processes. The specificity and efficacy of (S)-Anabasine in modulating nAChR activity enables researchers to explore the fundamental aspects of nicotinic receptor pharmacology, including receptor desensitization, ion channel kinetics, and the receptor′s role in synaptic transmission. This has broader implications for understanding the neurochemical basis of cognitive functions and neuroplasticity, thereby advancing the field of neuropharmacology and contributing to the development of novel research methodologies.