Date published: 2026-2-7

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S-(5′-Adenosyl)-L-homocysteine (CAS 979-92-0)

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Alternate Names:
5′-Deoxy-S-adenosyl-L-homocysteine; AdoHcy; S-(5′-Deoxyadenosine-5′)-L-homocysteine
Application:
S-(5′-Adenosyl)-L-homocysteine is an amino acid derivative that is an important intermediate in metabolic pathways
CAS Number:
979-92-0
Purity:
≥98%
Molecular Weight:
384.41
Molecular Formula:
C14H20N6O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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S-(5′-Adenosyl)-L-homocysteine is an amino acid derivative that is an important intermediate in metabolic pathways. The two most notable are the activated methyl cycle and the cysteine biosynthesis. It is also a product of S-adenosyl-methionine (SAM) dependent methylation of biological molecules. It is a key intermediate in the metabolism of methionine, cysteine, and other sulfur-containing compounds.


S-(5′-Adenosyl)-L-homocysteine (CAS 979-92-0) References

  1. Selective inhibitors of protein methyltransferases.  |  Kaniskan, HÜ., et al. 2015. J Med Chem. 58: 1596-629. PMID: 25406853
  2. Reversed phase and cation exchange liquid chromatography with spectrophotometric and elemental/molecular mass spectrometric detection for S-adenosyl methionine/S-adenosyl homocysteine ratios as methylation index in cell cultures of ovarian cancer.  |  Iglesias González, T., et al. 2015. J Chromatogr A. 1393: 89-95. PMID: 25836049
  3. H3K9 Trimethylation Silences Fas Expression To Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance.  |  Paschall, AV., et al. 2015. J Immunol. 195: 1868-82. PMID: 26136424
  4. LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation.  |  Lee, CH., et al. 2015. Oncotarget. 6: 25188-201. PMID: 26317789
  5. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.  |  Eram, MS., et al. 2016. ACS Chem Biol. 11: 772-781. PMID: 26598975
  6. Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors.  |  Yang, X., et al. 2016. J Med Chem. 59: 7617-33. PMID: 27468126
  7. Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).  |  Babault, N., et al. 2018. J Med Chem. 61: 1541-1551. PMID: 29320176
  8. Identification of protoberberine alkaloids as novel histone methyltransferase G9a inhibitors by structure-based virtual screening.  |  Chen, J., et al. 2018. J Comput Aided Mol Des. 32: 917-928. PMID: 30171419
  9. Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase.  |  Ducati, RG., et al. 2018. ACS Chem Biol. 13: 3173-3183. PMID: 30339406
  10. Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.  |  Shen, Y., et al. 2020. J Med Chem. 63: 5477-5487. PMID: 32367723
  11. Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1.  |  Chen, D., et al. 2021. ACS Med Chem Lett. 12: 485-493. PMID: 33738076
  12. High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice.  |  Lai, Y., et al. 2021. Nat Commun. 12: 6000. PMID: 34667167
  13. Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues.  |  Ahmed-Belkacem, R., et al. 2022. J Med Chem. 65: 6231-6249. PMID: 35439007
  14. Multi-omics eco-surveillance of complex legacy contamination with a locally adapted estuarine invertebrate.  |  Hillyer, KE., et al. 2023. Environ Pollut. 319: 120993. PMID: 36623788
  15. Post-prandial response in hepatopancreas and haemolymph of Penaeus monodon fed different diets. Omics insights into glycoconjugate metabolism, energy utilisation, chitin biosynthesis, immune function, and autophagy.  |  Mendoza-Porras, O., et al. 2023. Comp Biochem Physiol Part D Genomics Proteomics. 46: 101073. PMID: 37018937

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

S-(5′-Adenosyl)-L-homocysteine, 5 mg

sc-215826B
5 mg
$46.00

S-(5′-Adenosyl)-L-homocysteine, 10 mg

sc-215826
10 mg
$82.00

S-(5′-Adenosyl)-L-homocysteine, 25 mg

sc-215826A
25 mg
$122.00

S-(5′-Adenosyl)-L-homocysteine, 50 mg

sc-215826C
50 mg
$215.00