(S)-(−)-5-Fluorowillardiine (CAS 140187-23-1)
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(S)-(−)-5-Fluorowillardiine acts as a powerful inhibitor of protein phosphatase 2A (PP2A), a serine/threonine phosphatase that is fundamental to a myriad of cellular functions, such as cell division, DNA replication, and protein synthesis. (S)-(−)-5-Fluorowillardiine operates by attaching to the catalytic subunit of PP2A, thereby blocking the enzyme′s ability to remove phosphate groups from its substrates. This blockage results in an increased level of phosphorylated proteins within cells, which can influence a range of cellular activities. (S)-(−)-5-Fluorowillardiine is particularly recognized in the field of neuroscience research for its role as a selective agonist at the AMPA receptors, which are involved in fast synaptic transmission in the central nervous system.
(S)-(−)-5-Fluorowillardiine (CAS 140187-23-1) References
- Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. | Lee, RK., et al. 1995. Proc Natl Acad Sci U S A. 92: 8083-7. PMID: 7644542
- (S)-5-fluorowillardiine-mediated neurotoxicity in cultured murine cortical neurones occurs via AMPA and kainate receptors. | Larm, JA., et al. 1996. Eur J Pharmacol. 314: 249-54. PMID: 8957243
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-(−)-5-Fluorowillardiine, 10 mg | sc-361326 | 10 mg | $192.00 | |||
(S)-(−)-5-Fluorowillardiine, 50 mg | sc-361326A | 50 mg | $774.00 |