Molecular structure of (S)-4C-PG, CAS Number: 134052-73-6
(S)-4C-PG (CAS 134052-73-6)
Alternate Names:
(S)-4-Carboxyphenylglycine
Application:
(S)-4C-PG is a competitve group I mGluR antagonist with selectivity for mGluR-1
CAS Number:
134052-73-6
Purity:
≥97%
Molecular Weight:
195.17
Molecular Formula:
C9H9NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
(S)-4C-PG is a naturally occurring derivative of an amino acid known for its diverse biological activities and applications. As a chiral molecule, (S)-4C-PG exists in two distinct forms, each being the mirror image of the other, and can be synthesized using various methods. Although the precise mechanism of action of (S)-4C-PG is not yet fully understood, it is believed to exert its effects through multiple pathways. One proposed mechanism involves the modulation of enzyme and protein activity, as well as the regulation of various signaling pathways and receptors.
(S)-4C-PG (CAS 134052-73-6) References
- Dimethyl Fumarate Induces Glutathione Recycling by Upregulation of Glutathione Reductase. | Hoffmann, C., et al. 2017. Oxid Med Cell Longev. 2017: 6093903. PMID: 28116039
- The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells. | Sato, M., et al. 2018. Sci Rep. 8: 968. PMID: 29343855
- Amantadine Combines Astroglial System Xc- Activation with Glutamate/NMDA Receptor Inhibition. | Nakano, T., et al. 2019. Biomolecules. 9: PMID: 31108896
- Non-Opioid Neurotransmitter Systems that Contribute to the Opioid Withdrawal Syndrome: A Review of Preclinical and Human Evidence. | Dunn, KE., et al. 2019. J Pharmacol Exp Ther. 371: 422-452. PMID: 31391211
- Identification, Expression, and Roles of the Cystine/Glutamate Antiporter in Ocular Tissues. | Martis, RM., et al. 2020. Oxid Med Cell Longev. 2020: 4594606. PMID: 32655769
- xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling. | Liu, J., et al. 2020. Mol Ther. 28: 2358-2366. PMID: 32931751
- Dysregulation of Ambient Glutamate and Glutamate Receptors in Epilepsy: An Astrocytic Perspective. | Alcoreza, OB., et al. 2021. Front Neurol. 12: 652159. PMID: 33828523
- SLC7A11 as a Gateway of Metabolic Perturbation and Ferroptosis Vulnerability in Cancer. | Lee, J. and Roh, JL. 2022. Antioxidants (Basel). 11: PMID: 36552652
- Glutamate-GABA imbalance mediated by miR-8-5p and its STTM regulates phase-related behavior of locusts. | Yang, M., et al. 2023. Proc Natl Acad Sci U S A. 120: e2215660120. PMID: 36574679
- Effect of activity at metabotropic, as well as ionotropic (NMDA), glutamate receptors on morphine dependence. | Fundytus, ME. and Coderre, TJ. 1994. Br J Pharmacol. 113: 1215-20. PMID: 7889275
- Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. | Smith, SE., et al. 1993. Epilepsy Res. 15: 101-11. PMID: 8103738
- Synchronized oscillations in hippocampal CA3 neurons induced by metabotropic glutamate receptor activation. | Taylor, GW., et al. 1995. J Neurosci. 15: 8039-52. PMID: 8613741
Inhibitor of:
mGluR-1a.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-4C-PG, 1 mg | sc-203449 | 1 mg | $31.00 | |||
| US: Only available in the US | ||||||
(S)-4C-PG, 5 mg | sc-203449A | 5 mg | $153.00 | |||
| US: Only available in the US | ||||||
(S)-4C-PG, 50 mg | sc-203449B | 50 mg | $1102.00 | |||
| US: Only available in the US | ||||||