Molecular structure of (S)-3,4-DCPG, CAS Number: 201730-11-2
(S)-3,4-DCPG (CAS 201730-11-2)
Alternate Names:
(S)-3,4-Dicarboxyphenylglycine
Application:
(S)-3,4-DCPG is a potent and selective mGluR-8a agonist
CAS Number:
201730-11-2
Purity:
≥98%
Molecular Weight:
239.18
Molecular Formula:
C10H9NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(S)-3,4-DCPG is a potent, selective mGluR-8a agonist (EC50 = 31 nM). Displays > 100-fold selectivity over mGluR-1-7 and displays little/no activity at NMDA and kainate receptors.
(S)-3,4-DCPG (CAS 201730-11-2) References
- (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. | Thomas, NK., et al. 2001. Neuropharmacology. 40: 311-8. PMID: 11166323
- Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice. | Linden, AM., et al. 2003. Neuropharmacology. 45: 473-83. PMID: 12907308
- Differential roles of mGlu8 receptors in the regulation of glutamate and gamma-aminobutyric acid release at periaqueductal grey level. | Marabese, I., et al. 2005. Neuropharmacology. 49 Suppl 1: 157-66. PMID: 16084932
- Lack of the antianxiety-like effect of (S)-3,4-DCPG, an mGlu8 receptor agonist, after central administration in rats. | Stachowicz, K., et al. 2005. Pharmacol Rep. 57: 856-60. PMID: 16382208
- Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. | Marabese, I., et al. 2007. Neuropharmacology. 52: 253-62. PMID: 17113112
- Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus. | Jiang, FL., et al. 2007. Epilepsia. 48: 783-92. PMID: 17430409
- Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception. | Marabese, I., et al. 2007. J Neurophysiol. 98: 43-53. PMID: 17507496
- Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid. | Folbergrová, J., et al. 2008. Neuropharmacology. 54: 665-75. PMID: 18191956
- Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors. | Palazzo, E., et al. 2008. Neuropharmacology. 55: 537-45. PMID: 18533199
- Metabotropic glutamate receptor subtype 8 in the amygdala modulates thermal threshold, neurotransmitter release, and rostral ventromedial medulla cell activity in inflammatory pain. | Palazzo, E., et al. 2011. J Neurosci. 31: 4687-97. PMID: 21430167
- Selective agonism of mGlu8 receptors by (S)-3,4-dicarboxyphenylglycine does not affect sleep stages in the rat. | Cavas, M., et al. 2017. Pharmacol Rep. 69: 97-104. PMID: 27914294
- Structural Basis for (S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 Receptor. | Chen, Q., et al. 2018. J Med Chem. 61: 10040-10052. PMID: 30365309
- The inhibiting role of periaqueductal gray metabotropic glutamate receptor subtype 8 in a rat model of central neuropathic pain. | Hosseini, M., et al. 2020. Neurol Res. 42: 515-521. PMID: 32245335
- Evaluation of the Effect of (S)-3,4-Dicarboxyphenylglycine as a Metabotropic Glutamate Receptors Subtype 8 Agonist on Thermal Nociception Following Central Neuropathic Pain. | Hosseini, M., et al. 2021. Asian Spine J. 15: 200-206. PMID: 32460469
Activator of:
mGLuR-8, and mGluR-8a.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-3,4-DCPG, 10 mg | sc-204255 | 10 mg | $198.00 | |||
(S)-3,4-DCPG, 50 mg | sc-204255A | 50 mg | $817.00 |