Molecular structure of S-15176 difumarate salt, CAS Number: 148913-55-7
S-15176 difumarate salt (CAS 148913-55-7)
Alternate Names:
N-[(3,5-Di-tert-butyl-4-hydroxy-1-thiophenyl)]-3-propyl-N′-(2,3,4-trimethoxybenzyl)piperazine difumarate salt
CAS Number:
148913-55-7
Molecular Weight:
776.93
Molecular Formula:
C39H56N2O12S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
S-15176 difumarate salt is a research chemical primarily used to study mitochondrial function and bioenergetics. It acts as an inhibitor of the mitochondrial permeability transition pore (mPTP), which is a vital component in the regulation of cellular survival and apoptosis. This compound is of particular interest in the field of cellular biology, where it is used to explore the intracellular mechanisms that govern cell death and mitochondrial integrity. Its ability to modulate the mPTP makes it useful for researchers investigating the underlying processes of mitochondrial-related diseases and for those looking to understand the role of mitochondria in cellular stress responses.
S-15176 difumarate salt (CAS 148913-55-7) References
- The Effects of Difumarate Salt S-15176 after Spinal Cord Injury in Rats. | Erdoğan, H., et al. 2015. J Korean Neurosurg Soc. 57: 445-54. PMID: 26180614
- The Effect of S-15176 Difumarate Salt on Ultrastructure and Functions of Liver Mitochondria of C57BL/6 Mice with Streptozotocin/High-Fat Diet-Induced Type 2 Diabetes. | Belosludtseva, NV., et al. 2020. Biology (Basel). 9: PMID: 32987717
- Glucose fluctuation accelerates cardiac injury of diabetic mice via sodium-dependent glucose cotransporter 1 (SGLT1). | Wu, W., et al. 2021. Arch Biochem Biophys. 709: 108968. PMID: 34153296
- S-15176 Difumarate Salt Can Impair Mitochondrial Function through Inhibition of the Respiratory Complex III and Permeabilization of the Inner Mitochondrial Membrane. | Belosludtseva, NV., et al. 2022. Biology (Basel). 11: PMID: 35336754
- Uridine Administration Promotes Normalization of Heart Mitochondrial Function in Dystrophin-Deficient Mice and Decreases Tissue Fibrosis. | Dubinin, MV., et al. 2023. Bull Exp Biol Med. 176: 54-59. PMID: 38091140
- Effect of the Trimetazidine Derivative S-15176 Difumarate Salt on the Leukocyte Formula and Cytochemical Indices of the Peripheral Blood Neutrophils of C57BL/6 Mice in Experimental Type II Diabetes Mellitus. | Lebedeva, Ye A., et al. 2021. Opera Medica et Physiologica. 8.2: 25-34.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-15176 difumarate salt, 2 mg | sc-215828 | 2 mg | $138.00 | |||
S-15176 difumarate salt, 10 mg | sc-215828A | 10 mg | $408.00 |