S-100BB Antibody (3B10): sc-52204

S-100BB Antibody (3B10) is a mouse monoclonal IgG2a antibody that detects S-100BB protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-S-100BB antibody (3B10) is available in a non-conjugated form, specifically designed for researchers seeking to study the S-100 protein family, which includes important calcium-binding proteins that play critical roles in various cellular processes. S-100BB monoclonal antibody (3B10) recognizes proteins involved in regulating cellular functions such as cell cycle progression and differentiation, which are essential for maintaining normal cellular homeostasis and responding to stress. S-100 proteins interact with various other proteins, including receptor for advanced glycation end products (RAGE) and p53, influencing pathways related to inflammation and apoptosis. The S-100 protein family consists of two subunits, S-100 α chain and S-100 β chain, which can form different dimeric combinations, each with distinct biological activities. S-100 proteins are primarily localized in the cytoplasm and nuclei of specific cell types, including astrocytes and Schwann cells, and are also found in various tissues, such as benign and malignant melanocytic tumors. S-100 proteins′ ability to modulate calcium signaling and their involvement in pathological conditions make them valuable targets for research in neurobiology and cancer studies.

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S-100BB Antibody (3B10) References:

1. [Pathophysiologic aspects of S-100beta protein: a new biological marker of brain pathology].  |  Beaudeux, J., et al. 1999. Ann Biol Clin (Paris). 57: 261-72. PMID: 10377476
2. Isolation of a rat S100 alpha cDNA and distribution of its mRNA in rat tissues.  |  Zimmer, DB., et al. 1991. Brain Res Bull. 27: 157-62. PMID: 1742602
3. Calcium-binding proteins of the EF-type.  |  Heizmann, CW. 1988. J Cardiovasc Pharmacol. 12 Suppl 5: S30-7. PMID: 2469875
4. Interfering with S100B-effector protein interactions for cancer therapy.  |  Wu, KJ., et al. 2020. Drug Discov Today. 25: 1754-1761. PMID: 32679172
5. Developmental and functional studies of parvalbumin and calbindin D28K in hypothalamic neurons grown in serum-free medium.  |  Pfyffer, GE., et al. 1987. J Neurochem. 49: 442-51. PMID: 3298546
6. Developmental appearance of the Ca2+-binding proteins parvalbumin, calbindin D-28K, S-100 proteins and calmodulin during testicular development in the rat.  |  Kägi, U., et al. 1988. Cell Tissue Res. 252: 359-65. PMID: 3383215
7. S100B, Actor and Biomarker of Mild Traumatic Brain Injury.  |  Oris, C., et al. 2023. Int J Mol Sci. 24: PMID: 37047574
8. Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis.  |  Huang, X., et al. 2023. Nat Commun. 14: 7102. PMID: 37925548
9. Increase of skeletal muscle relaxation speed by direct injection of parvalbumin cDNA.  |  Müntener, M., et al. 1995. Proc Natl Acad Sci U S A. 92: 6504-8. PMID: 7604022
10. S100 protein expression in subpopulations of neurons of rat brain.  |  Rickmann, M. and Wolff, JR. 1995. Neuroscience. 67: 977-91. PMID: 7675218
11. Retinoic acid regulates the expression of the calcium binding protein, calbindin-D28K.  |  Wang, YZ. and Christakos, S. 1995. Mol Endocrinol. 9: 1510-21. PMID: 8584029
12. A novel calcium-binding protein in amniotic fluid, CAAF1: its molecular cloning and tissue distribution.  |  Hitomi, J., et al. 1996. J Cell Sci. 109 (Pt 4): 805-15. PMID: 8718672

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-S-100BB Antibody (3B10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-S-100BB Antibody (3B10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

S-100BB Antibody (3B10) Specifications

Alternate Product Name: S100 protein BB dimer (S100BB)

Product Clone Name: 3B10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: S-100 proteins

Epitope Species: human

Product Reactivity/Detection: S100BB

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for S-100BB Antibody (3B10): N/A

The preferred S-100 α/β chain antibody is S-100 α/β chain Antibody (B32.1): sc-58839.