S-100 α chain Antibody (0.N.555): sc-71992

S-100 α chain Antibody (0.N.555) is a mouse monoclonal IgG2a antibody that detects S-100 alpha chain protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-S-100 alpha chain antibody (0.N.555) is available as a non-conjugated format. The S-100 protein family, which includes S-100 α and β chains, plays a crucial role in various cellular processes, including cell cycle progression and differentiation regulation. S-100 alpha chain participates in calcium signaling by binding calcium ions and undergoing conformational changes that influence protein interactions. This calcium-binding capability enables calcium-induced calcium release, vital for numerous physiological processes, including muscle contraction and neurotransmitter release. S-100 proteins also inhibit microtubule assembly and modulate protein kinase C-mediated phosphorylation, highlighting their importance in cellular signaling pathways. S-100 protein predominantly localizes in the cytoplasm and nuclei of various cell types, including astrocytes and Schwann cells, and appears in benign and malignant melanocytic tumors, making S-100 alpha chain a significant marker in cancer research. With diverse applications and critical roles in cellular functions, S-100 alpha chain monoclonal antibody (0.N.555) serves as an invaluable tool for researchers studying calcium-binding proteins and their implications in health and disease.

The preferred S-100 α/β chain antibody is S-100 α/β chain Antibody (B32.1): sc-58839.