S-100 α/β chain Antibody (4B3): sc-52205

S-100 α/β chain Antibody (4B3) is a mouse monoclonal IgG2a antibody that detects the S-100 α/β chain protein of mouse, rat, and human by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). S-100 α and β chains are crucial members of the EF-hand type calcium-binding protein family, playing significant roles in various cellular processes, including cell cycle regulation and differentiation. These proteins are particularly important in the nervous system, where they are involved in the activation of calcium-induced calcium release, which is essential for neurotransmitter release and synaptic plasticity. S-100 proteins are predominantly localized in the cytoplasm and nuclei of astrocytes, Schwann cells, and certain tumors, such as ependymomas and astrogliomas, highlighting their relevance in both normal physiology and pathological conditions. The presence of S-100 in benign and malignant melanocytic tumors, as well as in Langerhans cells in the skin, underscores its potential as a biomarker for various diseases. S-100 α and β chains form dimeric complexes, which can consist of two α chains, two β chains, or one of each, and their interactions with other proteins can influence cellular signaling pathways, making them vital for understanding cellular responses to calcium fluctuations. Anti-S-100 α/β chain antibody (4B3) is an invaluable tool for researchers investigating the roles of these proteins in health and disease.

The preferred S-100 α/β chain antibody is S-100 α/β chain Antibody (B32.1): sc-58839.