Molecular structure of S-(+)-Niguldipine hydrochloride, CAS Number: 113165-32-5
S-(+)-Niguldipine hydrochloride (CAS 113165-32-5)
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Alternate Names:
S(+)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride
Application:
S-(+)-Niguldipine hydrochloride is a calcium channel protein inhibitor
CAS Number:
113165-32-5
Molecular Weight:
646.18
Molecular Formula:
C36H39N3O6•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
S-(+)-Niguldipine hydrochloride is an L-type calcium channel protein inhibitor and alpha1A-AR adrenoceptor antagonist. S-(+)-Niguldipine hydrochloride is the more active enantiomer relative to (R)-(−)-Niguldipine hydrochloride (sc-203676). Its mechanism of action involves selective blocking of L-type calcium channels, which play a role in regulating the flow of calcium ions into cells. Through this blockade, niguldipine effectively reduces the influx of calcium ions, leading to decreased muscle contraction, vasodilation, and other significant physiological effects.
S-(+)-Niguldipine hydrochloride (CAS 113165-32-5) References
- Characterisation of alpha1B-adrenoceptors linked to inositol phosphate formation and calcium mobilisation in human astrocytoma U373 MG cells. | Arias-Montaño, JA., et al. 1999. Naunyn Schmiedebergs Arch Pharmacol. 360: 533-9. PMID: 10598792
- alpha(1D)-adrenoceptors cause endothelium-dependent vasodilatation in the rat mesenteric vascular bed. | Filippi, S., et al. 2001. J Pharmacol Exp Ther. 296: 869-75. PMID: 11181918
- Noradrenaline increases the firing rate of a subpopulation of rat subthalamic neurones through the activation of alpha 1-adrenoceptors. | Arcos, D., et al. 2003. Neuropharmacology. 45: 1070-9. PMID: 14614950
- Trophic effects induced by alpha1D-adrenoceptors on endothelial cells are potentiated by hypoxia. | Vinci, MC., et al. 2007. Am J Physiol Heart Circ Physiol. 293: H2140-7. PMID: 17660397
- Stereoselective inhibition of thromboxane-induced coronary vasoconstriction by 1,4-dihydropyridine calcium channel antagonists. | Eltze, M., et al. 1990. Chirality. 2: 233-40. PMID: 1964575
- Niguldipine discriminates between alpha 1-adrenoceptor-mediated second messenger responses in rat cerebral cortex slices. | Robinson, JP. and Kendall, DA. 1990. Br J Pharmacol. 100: 3-4. PMID: 2164859
- Investigation of the effects of α1-adrenoceptor antagonism and L-type calcium channel blockade on ejaculation and vas deferens and seminal vesicle contractility in vitro. | de Almeida Kiguti, LR. and Pupo, AS. 2012. J Sex Med. 9: 159-68. PMID: 21810189
- Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells. | Klöckner, U., et al. 1989. Arzneimittelforschung. 39: 120-6. PMID: 2541731
- (+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors. | Boer, R., et al. 1989. Eur J Pharmacol. 172: 131-45. PMID: 2548881
- Stereoselective binding of niguldipine enantiomers to alpha 1A-adrenoceptors labeled with [3H]5-methyl-urapidil. | Graziadei, I., et al. 1989. Eur J Pharmacol. 172: 329-37. PMID: 2555206
- Adrenal fasciculata cells express T-type and rapidly and slowly activating L-type Ca2+ channels that regulate cortisol secretion. | Enyeart, JJ. and Enyeart, JA. 2015. Am J Physiol Cell Physiol. 308: C899-918. PMID: 25788571
- Functional characterisation of alpha 1-adrenoceptor subtypes mediating noradrenaline-induced inositol phosphate formation in rat thalamus slices. | Trejo, F., et al. 1996. Eur J Pharmacol. 318: 175-84. PMID: 9007530
- Noradrenaline-induced inositol phosphate formation in rat striatum is mediated by alpha 1A-adrenoceptors. | Arias-Montaño, JA., et al. 1996. Neuropharmacology. 35: 1605-13. PMID: 9025108
Inhibitor of:
alpha1A-AR, and Calcium Channel Protein.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-(+)-Niguldipine hydrochloride, 10 mg | sc-203248 | 10 mg | $408.00 |