S-(−)-Nicotine ditartrate dihydrate (CAS 6019-06-3)
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S-(−)-Nicotine ditartrate dihydrate is a specific enantiomer and salt form of nicotine. The tartrate salt form of this specific enantiomer offers improved stability and solubility compared to freebase nicotine, making it especially suitable for various experimental setups, including biochemical assays. It is a potent neurotoxin and AChR (nicotinic acetylcholine receptor) activator. S-(−)-Nicotine ditartrate dihydrate is found to be the naturally occurring isomer form. By using this form of nicotine, researchers can precisely control dosage and concentration in experimental models, enabling detailed studies on how nicotine influences neurotransmitter release and receptor activation. Moreover, the use of S-(−)-Nicotine ditartrate dihydrate extends to analytical chemistry, where it is used as a standard in chromatographic and spectroscopic methods for the quantification of nicotine in biological samples, environmental samples, and tobacco products.
S-(−)-Nicotine ditartrate dihydrate (CAS 6019-06-3) References
- Activation by nicotine of striatal neurons receiving excitatory input from the substantia nigra via dopamine release. | Yu, H., et al. 2000. Brain Res. 872: 223-6. PMID: 10924698
- Oral nicotine administration decreases tumor necrosis factor-alpha expression in fat tissues in obese rats. | Liu, RH., et al. 2001. Metabolism. 50: 79-85. PMID: 11172479
- Benzylidene anabaseines act as high-affinity agonists for insect nicotinic acetylcholine receptors. | Sultana, I., et al. 2002. Insect Biochem Mol Biol. 32: 637-43. PMID: 12020838
- Transport mechanisms of nicotine across the human intestinal epithelial cell line Caco-2. | Fukada, A., et al. 2002. J Pharmacol Exp Ther. 302: 532-8. PMID: 12130712
- Long-term oral nicotine administration reduces insulin resistance in obese rats. | Liu, RH., et al. 2003. Eur J Pharmacol. 458: 227-34. PMID: 12498930
- Distinct transport activity of tetraethylammonium from L-carnitine in rat renal brush-border membranes. | Ohnishi, S., et al. 2003. Biochim Biophys Acta. 1609: 218-24. PMID: 12543384
- A beta-induced TNF-alpha expression and acetylcholine action in mouse glial cells. | Nomura, J., et al. 2003. Life Sci. 72: 2117-20. PMID: 12628466
- Effect of nicotine-induced corticosterone elevation on nitric oxide production in the passive skin arthus reaction in rats. | Kubo, K., et al. 2004. J Pharmacol Sci. 94: 31-8. PMID: 14745115
- The expression and functional role of nicotinic acetylcholine receptors in rat adipocytes. | Liu, RH., et al. 2004. J Pharmacol Exp Ther. 310: 52-8. PMID: 14993259
- Involvement of specific transport system of renal basolateral membranes in distribution of nicotine in rats. | Fukada, A., et al. 2002. Drug Metab Pharmacokinet. 17: 554-60. PMID: 15618711
- Pancuronium enhances isoflurane anesthesia in rats via inhibition of cerebral nicotinic acetylcholine receptors. | Miyazaki, Y., et al. 2016. J Anesth. 30: 671-6. PMID: 27146658
- Effect of Cigarette Smoking on Functional Outcomes in Patients with Spontaneous Intracerebral Hemorrhage. | Ironside, N., et al. 2019. J Stroke Cerebrovasc Dis. 28: 2496-2505. PMID: 31279697
- Nicotine promotes angiogenesis in mouse brain after intracerebral hemorrhage. | Matsumoto, K., et al. 2021. Neurosci Res. 170: 284-294. PMID: 32673702
- Neutrophil extracellular traps-mediated Beclin-1 suppression aggravates atherosclerosis by inhibiting macrophage autophagy. | Sano, M., et al. 2022. Front Cell Dev Biol. 10: 876147. PMID: 35923856
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-(−)-Nicotine ditartrate dihydrate, 5 g | sc-212381 | 5 g | $408.00 |