Molecular structure of S-(+)-CBPG
S-(+)-CBPG
Alternate Names:
S-(+)-2-(3'-Carboxybicyclo[1.1.1]pentyl)glycine; UPF 596
Application:
S-(+)-CBPG is a structurally new group I mGluR antagonist
Molecular Weight:
185.17
Molecular Formula:
C8H11NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
S-(+)-CBPG is a potent and selective, structurally new group I metabotropic glutamate receptor (mGluR) antagonist.
S-(+)-CBPG References
- Metabotropic G-protein-coupled glutamate receptors as therapeutic targets. | Pellicciari, R. and Costantino, G. 1999. Curr Opin Chem Biol. 3: 433-40. PMID: 10419848
- Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity. | Mannaioni, G., et al. 1999. Neuropharmacology. 38: 917-26. PMID: 10428410
- Asymmetric synthesis of some substituted-3-phenyl prolines. | Micheli, F., et al. 1999. Farmaco. 54: 461-4. PMID: 10486913
- Pharmacological agents acting at subtypes of metabotropic glutamate receptors. | Schoepp, DD., et al. 1999. Neuropharmacology. 38: 1431-76. PMID: 10530808
- Induction of LTD by activation of group I mGluR in the dentate gyrus in vitro. | Camodeca, N., et al. 1999. Neuropharmacology. 38: 1597-606. PMID: 10530821
- Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms. | Pellegrini-Giampietro, DE., et al. 1999. Neuropharmacology. 38: 1607-19. PMID: 10530822
- 1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia. | Pellegrini-Giampietro, DE., et al. 1999. Eur J Neurosci. 11: 3637-47. PMID: 10564371
- (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist. | Pellicciari, R., et al. 1996. J Med Chem. 39: 2874-6. PMID: 8709120
- Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex. | Moroni, F., et al. 1998. Eur J Pharmacol. 347: 189-95. PMID: 9653880
- mGluRs novel ligands and molecular modeling studies[J]. | Pellicciari R, Costantino G, Marinozzi M. 1996. Neuropharmacology,., 6(35):: A23.
Inhibitor of:
mGluR-1a, mGluR-1b, and mGluR-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-(+)-CBPG, 1 mg | sc-222268 | 1 mg | $35.00 | |||
S-(+)-CBPG, 5 mg | sc-222268A | 5 mg | $133.00 |