RXRβ Antibody (11-13): sc-742

RXRβ Antibody (11-13) is a mouse monoclonal IgG1 kappa light chain antibody that detects human RXR beta protein by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RXRβ (11-13) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. RXR beta protein plays a crucial role in the regulation of gene expression as a member of the retinoid X receptor family, which is essential for mediating the effects of retinoic acid, a vital signaling molecule involved in numerous biological processes such as cell differentiation, growth, and development. RXR beta, along with isoforms RXRα and RXRγ, forms heterodimers with other nuclear receptors, including retinoic acid receptors (RARs), thyroid hormone receptors, and vitamin D3 receptors, thereby influencing a wide array of physiological functions. RXR beta interaction with various ligands, including 9-cis-retinoic acid, highlights importance in cellular signaling pathways and potential implications in developmental biology and disease states. RXRβ (11-13) monoclonal antibody enables valuable insights into functional dynamics of RXR beta and role in gene regulation and cellular processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

RXRβ Antibody (11-13) References:

1. 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha.  |  Levin, AA., et al. 1992. Nature. 355: 359-61. PMID: 1309942
2. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.  |  Heyman, RA., et al. 1992. Cell. 68: 397-406. PMID: 1310260
3. Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor.  |  Yang, N., et al. 1991. Proc Natl Acad Sci U S A. 88: 3559-63. PMID: 1850832
4. The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily.  |  Koelle, MR., et al. 1991. Cell. 67: 59-77. PMID: 1913820
5. A functional retinoic acid receptor encoded by the gene on human chromosome 12.  |  Ishikawa, T., et al. 1990. Mol Endocrinol. 4: 837-44. PMID: 2172793
6. A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer.  |  Liu, RZ., et al. 2012. J Pathol. 228: 310-21. PMID: 22322885
7. Nuclear RXRα and RXRβ receptors exert distinct and opposite effects on RA-mediated neuroblastoma differentiation.  |  Girardi, CS., et al. 2019. Biochim Biophys Acta Mol Cell Res. 1866: 317-328. PMID: 30529222
8. Role of RXRβ in platelet function and arterial thrombosis.  |  Lüsebrink, E., et al. 2019. J Thromb Haemost. 17: 1489-1499. PMID: 31172692
9. MDM2-Mediated Ubiquitination of RXRβ Contributes to Mitochondrial Damage and Related Inflammation in Atherosclerosis.  |  Zeng, Y., et al. 2022. Int J Mol Sci. 23: PMID: 35628577
10. Rational Design of a New RXR Agonist Scaffold Enabling Single-Subtype Preference for RXRα, RXRβ, and RXRγ.  |  Adouvi, G., et al. 2023. J Med Chem. 66: 333-344. PMID: 36533416
11. Phase separation propensity of the intrinsically disordered AB region of human RXRβ.  |  Sołtys, K. and Ożyhar, A. 2023. Cell Commun Signal. 21: 92. PMID: 37143076
12. Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor.  |  Bhat, MK., et al. 1994. Proc Natl Acad Sci U S A. 91: 7927-31. PMID: 8058736

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RXRβ Antibody (11-13) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-RXRβ Antibody (11-13) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RXRβ Antibody (11-13) Specifications

Alternate Product Name: RXRβ

Product Clone Name: 11-13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: RXRβ

Epitope Species: human

Product Reactivity/Detection: RXRβ₁ and RXRβ₂

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for RXRβ Antibody (11-13): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred RXRα/β/γ antibody is RXRα/β/γ Antibody (F-1): sc-46659.