Date published: 2026-5-8

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RX 821002 hydrochloride (CAS 109544-45-8)

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Alternate Names:
2-(2,3-Dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
Application:
RX 821002 hydrochloride is a selective α2-adrenoceptor antagonist
CAS Number:
109544-45-8
Purity:
≥98%
Molecular Weight:
270.71
Molecular Formula:
C12H14N2O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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RX 821002 hydrochloride is a compound that functions as an antagonist at the α2-adrenergic receptor. It acts by inhibiting the binding of norepinephrine to the receptor, thereby blocking the downstream signaling pathways mediated by this receptor. RX 821002 hydrochloride targets the α2-adrenergic receptor subtype, leading to a reduction in its activity and subsequent effects on cellular function. By interfering with the receptor-ligand interaction, RX 821002 hydrochloride modulates the physiological responses mediated by α2-adrenergic receptors in experimental models. RX 821002 hydrochloride′s mechanism of action involves disrupting the normal signaling cascade initiated by norepinephrine binding, ultimately influencing cellular processes regulated by α2-adrenergic receptor activation. In and development applications, RX 821002 hydrochloride is utilized to investigate the specific role of α2-adrenergic receptors in various physiological and pathological conditions, providing insights into the molecular mechanisms underlying these processes.


RX 821002 hydrochloride (CAS 109544-45-8) References

  1. The alpha 2 adrenoceptor antagonists RX 821002 and yohimbine delay-dependently impair choice accuracy in a delayed non-matching-to-position task in rats.  |  McAllister, KH. 2001. Psychopharmacology (Berl). 155: 379-88. PMID: 11441427
  2. Long-lasting effects of yohimbine on the ejaculatory function in male dogs.  |  Yonezawa, A., et al. 2005. Biomed Res. 26: 201-6. PMID: 16295696
  3. Pharmacologic characterization of the cloned human trace amine-associated receptor1 (TAAR1) and evidence for species differences with the rat TAAR1.  |  Wainscott, DB., et al. 2007. J Pharmacol Exp Ther. 320: 475-85. PMID: 17038507
  4. Detection of alpha2-adrenergic receptors in brain of living pig with 11C-yohimbine.  |  Jakobsen, S., et al. 2006. J Nucl Med. 47: 2008-15. PMID: 17138744
  5. Dopamine binds to alpha(2)-adrenergic receptors in the song control system of zebra finches (Taeniopygia guttata).  |  Cornil, CA., et al. 2008. J Chem Neuroanat. 35: 202-15. PMID: 18155403
  6. Interplay among catecholamine systems: dopamine binds to alpha2-adrenergic receptors in birds and mammals.  |  Cornil, CA. and Ball, GF. 2008. J Comp Neurol. 511: 610-27. PMID: 18924139
  7. Selective enhancement of mesocortical dopaminergic transmission by noradrenergic drugs: therapeutic opportunities in schizophrenia.  |  Masana, M., et al. 2011. Int J Neuropsychopharmacol. 14: 53-68. PMID: 20701825
  8. Amphetamine and cocaine suppress social play behavior in rats through distinct mechanisms.  |  Achterberg, EJ., et al. 2014. Psychopharmacology (Berl). 231: 1503-15. PMID: 24057815
  9. Effects of imidazolines and derivatives on insulin secretion and vascular resistance in perfused rat pancreas.  |  Berdeu, D., et al. 1994. Eur J Pharmacol. 254: 119-25. PMID: 7911426
  10. Affinity of detomidine, medetomidine and xylazine for alpha-2 adrenergic receptor subtypes.  |  Schwartz, DD. and Clark, TP. 1998. J Vet Pharmacol Ther. 21: 107-11. PMID: 9597647
  11. Effect of YNS-15P, a new alpha-2 adrenoceptor antagonist, on stress-stimulated colonic propulsion in rats.  |  Yamamoto, O., et al. 1998. J Pharmacol Exp Ther. 287: 691-6. PMID: 9808698
  12. Post-hypoxia frequency decline in rats: sensitivity to repeated hypoxia and alpha2-adrenoreceptor antagonism.  |  Bach, KB., et al. 1999. Brain Res. 817: 25-33. PMID: 9889307
  13. Inverse agonism at α2-adrenoceptors in native tissue  |  L.Charles Murrin, Moira E Gerety, H.Kevin Happe, David B Bylund. 2000. European Journal of Pharmacology. 398: 185-191.
  14. Evaluation of [11C]GB67, a novel radioligand for imaging myocardial α1-adrenoceptors with positron emission tomography  |  Marilyn P. Law, Safiye Osman, Victor W. Pike, Raymond J. Davenport, Vincent J. Cunningham, Ornella Rimoldi, Christopher G. Rhodes, Dario Giardinà & Paolo G. Camici. 2000. European Journal of Nuclear Medicine. 27: 7–17.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

RX 821002 hydrochloride, 10 mg

sc-203686
10 mg
$71.00

RX 821002 hydrochloride, 50 mg

sc-203686A
50 mg
$269.00