Molecular structure of RWJ 67657, CAS Number: 215303-72-3
RWJ 67657 (CAS 215303-72-3)
See product citations (2)
Alternate Names:
4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol
Application:
RWJ 67657 is a p38/JNK kinase inhibitor with anti-inflammatory properties
CAS Number:
215303-72-3
Purity:
≥95%
Molecular Weight:
425.5
Molecular Formula:
C27H24FN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RWJ 67657 is a p38/JNK kinase inhibitor with anti-inflammatory properties. Studies show that RWJ 67657 blocks TNF-α production. RWJ 67657 has been shown to block HIV replication in T-cell and monocyte cells. Additional studies report a decrease of chemokine production, E-selectin, IL-8, and COX-2 expression in the presence of RWJ 67657. RWJ 67657 is an inhibitor of p38 α and p38 β.
RWJ 67657 (CAS 215303-72-3) References
- RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. | Wadsworth, SA., et al. 1999. J Pharmacol Exp Ther. 291: 680-7. PMID: 10525088
- Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657, a specific p38 mitogen-activated protein kinase inhibitor: a first-in-human study. | Parasrampuria, DA., et al. 2003. J Clin Pharmacol. 43: 406-13. PMID: 12723461
- Effects of RWJ 67657, a p38 mitogen activated protein kinase (MAPK) inhibitor, on the production of inflammatory mediators by rheumatoid synovial fibroblasts. | Westra, J., et al. 2004. Ann Rheum Dis. 63: 1453-9. PMID: 15479895
- Chemokine production and E-selectin expression in activated endothelial cells are inhibited by p38 MAPK (mitogen activated protein kinase) inhibitor RWJ 67657. | Westra, J., et al. 2005. Int Immunopharmacol. 5: 1259-69. PMID: 15914330
- Baicalin inhibits TLR2/4 signaling pathway in rat brain following permanent cerebral ischemia. | Tu, XK., et al. 2011. Inflammation. 34: 463-70. PMID: 20859668
- [Baicalin prevents the up-regulation of connective tissue growth factor in fibrotic lungs of rats]. | Jia, H., et al. 2010. Sheng Li Xue Bao. 62: 535-40. PMID: 21170500
- Synergistic Effects of Transplanted Endothelial Progenitor Cells and RWJ 67657 in Diabetic Ischemic Stroke Models. | Bai, YY., et al. 2015. Stroke. 46: 1938-46. PMID: 26045601
- Anti-Toxoplasma gondii screening of MMV pandemic response box and evaluation of RWJ-67657 efficacy in chronically infected mice. | Dos Santos, BR., et al. 2023. Parasitology. 150: 1226-1235. PMID: 37859414
- The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin. | Lin, CC. and Shieh, DE. 1996. Am J Chin Med. 24: 31-6. PMID: 8739179
- Baicalin, an inhibitor of HIV-1 production in vitro. | Kitamura, K., et al. 1998. Antiviral Res. 37: 131-40. PMID: 9588845
Inhibitor of:
ICAM, JNK, p38 alpha, Pbs2, Ser/Thr Protein Kinase, Tyrosine Kinase, and V1RA4.Activator of:
p38γ.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RWJ 67657, 10 mg | sc-204251 | 10 mg | $185.00 | |||
RWJ 67657, 50 mg | sc-204251A | 50 mg | $772.00 |