Molecular structure of Ruthenium red, CAS Number: 11103-72-3
Ruthenium red (CAS 11103-72-3)
See product citations (13)
Alternate Names:
Ammoniated ruthenium oxychloride; Ruthenium (III) Chloride Oxide Ammoniated; RR
Application:
Ruthenium red is a voltage-sensitive calcium channel inhibitor
CAS Number:
11103-72-3
Molecular Weight:
786.35
Molecular Formula:
Cl6H42N14O2Ru3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ruthenium red blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release. Additionally, Ruthenium red blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Ruthenium red is an inhibitor of Calcium Channel Protein, SERCA and TRPV. Ruthenium red is an inhibitor of CaM and Troponin C.
Ruthenium red (CAS 11103-72-3) References
- Effects of ruthenium red on activation of Ca2(+)-dependent cyclic nucleotide phosphodiesterase. | Masuoka, H., et al. 1990. Biochem Biophys Res Commun. 169: 315-22. PMID: 1693502
- Interaction of ruthenium red with Ca2(+)-binding proteins. | Charuk, JH., et al. 1990. Anal Biochem. 188: 123-31. PMID: 1699445
- Effects of ruthenium red on excitation and contraction in muscle fibres with Ca2+ electrogenesis. | Zacharová, D., et al. 1990. Gen Physiol Biophys. 9: 545-68. PMID: 1706675
- Piezo proteins are pore-forming subunits of mechanically activated channels. | Coste, B., et al. 2012. Nature. 483: 176-81. PMID: 22343900
- Ruthenium red colorimetric and birefringent staining of amyloid-β aggregates in vitro and in Tg2576 mice. | Cook, NP., et al. 2013. ACS Chem Neurosci. 4: 379-84. PMID: 23509974
- The effects of ruthenium red on the response of guinea-pig ileum to capsaicin. | Chahl, LA. 1989. Eur J Pharmacol. 169: 241-7. PMID: 2478375
- Ruthenium red improves blastocyst developmental competence by regulating mitochondrial Ca2+ and mitochondrial functions in fertilized porcine oocytes in vitro. | Jegal, HG., et al. 2020. J Reprod Dev. 66: 377-386. PMID: 32321875
- Functional Expression of Piezo1 in Dorsal Root Ganglion (DRG) Neurons. | Roh, J., et al. 2020. Int J Mol Sci. 21: PMID: 32481599
- Ruthenium red, mitochondrial calcium uniporter inhibitor, attenuates cognitive deficits in STZ-ICV challenged experimental animals. | Sharma, Y. and Garabadu, D. 2020. Brain Res Bull. 164: 121-135. PMID: 32858127
- Ruthenium red attenuates brown adipose tissue thermogenesis in rats. | Vizin, RCL., et al. 2021. J Therm Biol. 95: 102779. PMID: 33454027
- Ruthenium red: a highly efficient and versatile cell staining agent for single-cell analysis using inductively coupled plasma time-of-flight mass spectrometry. | Qin, W., et al. 2021. Analyst. 146: 6753-6759. PMID: 34643628
- Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. | Neuberger, A., et al. 2021. Nat Commun. 12: 6284. PMID: 34725357
- MCU Inhibitor Ruthenium Red Alleviates the Osteoclastogenesis and Ovariectomized Osteoporosis via Suppressing RANKL-Induced ROS Production and NFATc1 Activation through P38 MAPK Signaling Pathway. | Wang, Y., et al. 2022. Oxid Med Cell Longev. 2022: 7727006. PMID: 36148414
- Ruthenium red attenuates acute pancreatitis by inhibiting MCU and improving mitochondrial function. | Yu, X., et al. 2022. Biochem Biophys Res Commun. 635: 236-243. PMID: 36283336
- Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red. | Bernardi, P., et al. 1984. Biochemistry. 23: 1645-51. PMID: 6202317
Inhibitor of:
6330403A02Rik, ANKTM1, ASIC1, AY026312, BSPII, C10orf63, C18orf30, C18orf58, C6orf105, C8β, CaBP1, CaBP5, Calbindin D28K, Calcium Channel Protein, CALHM1, CALHM2, Calmegin, CALR4, CaM, CaM V, CatSperβ, CCDC109A, CCDC109B, CCDC90A, CHERP, CIB2, CRISP-4, CUTA, DDX19A, DDX35, DNAH5, EG546368, EG631584, FucU, Gm5849, Grancalcin, Grpa, GSDML, hippocalcin, HRC, Junctional SR Marker, Junctophilin-3, Keg1, KLH-B, Metaxin 3, Mitsugumin23, Morc2b, MrgA2, MrgA3, MrgA4, MrgA8, MrgA9, MrgB4, MRS2L, mucolipin 1, Munc13-3, NCKX1, NCX2, neurocalcin, NIPA1, ODR4, Olfr1099, Olfr1107, Olfr1166, Olfr16, Olfr31, Olfr315, Olfr319, Olfr324, Olfr33, Olfr331, Olfr332, Olfr338, Olfr342, Olfr347, Olfr348, Olfr352, Olfr356, Olfr358, Olfr370, Olfr536, Olfr544, Olfr551, Olfr651, Olfr665, Olfr722, Olfr870, Olfr873, OR10AG1, OR10K2, OR1J1, OR1J2, OR2AP1, OR2J2, OR2S2, OR2T34, OR2V1, OR4D9, OR51I, OR5H15, OR5K2, OR5K4, OR5V1, OR6C1, OR6C6, OR6C68, OR6C74, OR6C76, OR9A2, Ost1, OTOP1, OTRPC4, PIEZO1, PIRT, PMCA2, PMCA4, PMCA4b, PMR1, Polycystin-2, Polycystin-L2, Recoverin, reticulocalbin-3, RyR-1, RyR-2, RyR-3, SERCA, SLC25A21, SLC25A43, SLC41A3, SLM-1, sorcin, Stim2, STOML3, THIK-1, Tim50, TMCO5, TMEM120B, TMEM150C, TMEM165, TMEM17, TMEM184B, TMEM63A, TMEM63B, TMEM63C, TMEM80, TMEM86B, TMTC2, TMX3, Tom40B, Tom7, TPCN2, TREK-2, Trk1, Troponin C, TRP14, Trp3, Trp4, Trp5, Trp6, TRPC4AP, TRPV, TRPV3, TRPV6, Tuftelin, UCP1, UNC-13, V1rg10, V1RG4, V1RG5, V1RH2, V1RH4, V1RL5, V3R 8, VDAC1, VILIP-3, Vmn1r90, Vmn2r106, Vmn2r107, Vmn2r20, Vmn2r79, Vmn2r94, and Vmn2r99.Activator of:
6330403A02Rik, AQP12, ASIC-β, ASIC4, ATP8B5, BC060267, CALR3, CaM V, CBARA1, Clca6, D630042P16Rik, Gm5849, IP3R-III, LTRPC7, MrgB3, nucleobindin, Olfr1008, Olfr1080, Olfr1104, OTOP1, PRRT4, SCaMC-1, Synaptogyrin-2, Syntaxin 2, TMC4, TMEM150C, TMEM16F, TMEM38B, TPCN1, TRPC5, TRPV4, UCP2, and VRL-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ruthenium red, 500 mg | sc-202328 | 500 mg | $188.00 | |||
Ruthenium red, 1 g | sc-202328A | 1 g | $250.00 |