Molecular structure of Rupintrivir, CAS Number: 223537-30-2
Rupintrivir (CAS 223537-30-2)
See product citations (19)
Alternate Names:
AG 7088
Application:
Rupintrivir is an irreversible inhibitor of HRV 3C protease
CAS Number:
223537-30-2
Purity:
≥98%
Molecular Weight:
598.66
Molecular Formula:
C31H39FN4O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Rupintrivir is an irreversible HRV 3C protease inhibitor, demonstrating in vitro activity against all HRVs tested. HRV 3C protease is essential for the replication of the rhinovirus. By targeting this specific enzyme, rupintrivir helps to disrupt the virus′s life cycle, preventing it from maturing and proliferating. Rupintrivir, belonging to the class of antifolates, is a potent small molecule inhibitor targeting the enzyme dihydrofolate reductase (DHFR). In laboratory applications, in vitro experiments employ cell cultures to investigate the impact of rupintrivir on cellular behavior and response.
Rupintrivir (CAS 223537-30-2) References
- Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor. | Binford, SL., et al. 2005. Antimicrob Agents Chemother. 49: 619-26. PMID: 15673742
- In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease. | Binford, SL., et al. 2007. Antimicrob Agents Chemother. 51: 4366-73. PMID: 17908951
- Lack of respiratory and contact sensitizing potential of the intranasal antiviral drug candidate rupintrivir (AG7088): a weight-of-the-evidence evaluation. | Burns-Naas, LA., et al. 2005. J Immunotoxicol. 2: 123-39. PMID: 18958666
- Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection. | Zhang, XN., et al. 2010. World J Gastroenterol. 16: 201-9. PMID: 20066739
- Synergistic inhibition of enterovirus 71 replication by interferon and rupintrivir. | Hung, HC., et al. 2011. J Infect Dis. 203: 1784-90. PMID: 21536800
- Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: evaluation of antiviral efficacy in a murine infection model. | Zhang, X., et al. 2013. Antiviral Res. 97: 264-9. PMID: 23295352
- Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir. | Wu, C., et al. 2013. Acta Crystallogr D Biol Crystallogr. 69: 866-71. PMID: 23633597
- The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon. | Rocha-Pereira, J., et al. 2014. Antimicrob Agents Chemother. 58: 4675-81. PMID: 24890597
- In Vitro Assessment of Combinations of Enterovirus Inhibitors against Enterovirus 71. | Wang, Y., et al. 2016. Antimicrob Agents Chemother. 60: 5357-67. PMID: 27353263
- Rupintrivir reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo. | Danov, O., et al. 2019. Respir Res. 20: 228. PMID: 31640701
- Antimicrobial peptides and other peptide-like therapeutics as promising candidates to combat SARS-CoV-2. | Mousavi Maleki, MS., et al. 2021. Expert Rev Anti Infect Ther. 19: 1205-1217. PMID: 33844613
- DWV 3C Protease Uncovers the Diverse Catalytic Triad in Insect RNA Viruses. | Yuan, X. and Kadowaki, T. 2022. Microbiol Spectr. 10: e0006822. PMID: 35575593
- Molecular docking study of various Enterovirus-A71 3C protease proteins and their potential inhibitors. | Le, TTV. and Do, PC. 2022. Front Microbiol. 13: 987801. PMID: 36246267
Inhibitor of:
Protease.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rupintrivir, 1 mg | sc-208317 | 1 mg | $416.00 |