RU58841 (CAS 154992-24-2)
Alternate Names:
4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile
CAS Number:
154992-24-2
Molecular Weight:
369.34
Molecular Formula:
C17H18F3N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RU58841 is a compound primarily investigated for its potential effects on androgen receptors. It is employed to study androgen-related pathways and their association with various conditions. The compound′s mode of action is of particular interest; it is known to competitively inhibit the binding of dihydrotestosterone (DHT) to androgen receptors, thereby potentially reducing the downstream effects that DHT has on tissue. RU58841 is used in cell culture studies to elucidate the role of androgens in cellular growth processes and the development of certain tissues. In addition, RU58841 has been utilized in research to explore the mechanisms that underlie sebaceous gland activity and the skin′s response to androgen stimulation.
RU58841 (CAS 154992-24-2) References
- Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily. | Lee, YF., et al. 1999. Proc Natl Acad Sci U S A. 96: 14724-9. PMID: 10611280
- Roles of testosterone in the growth of keratinocytes through bald frontal dermal papilla cells. | Pan, HJ., et al. 1999. Endocrine. 11: 321-7. PMID: 10786829
- Synthesis and structure-activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands. | Van Dort, ME. and Jung, YW. 2001. Bioorg Med Chem Lett. 11: 1045-7. PMID: 11327585
- Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles. | Lin, Y., et al. 2022. Pharmaceutics. 14: PMID: 35890299
- Effects of Baicalin on Alopecia and the Associated Mechanism. | Chen, L., et al. 2022. Biomed Res Int. 2022: 3139123. PMID: 36440360
- Identification of a minimum number of genes to predict triple-negative breast cancer subgroups from gene expression profiles. | Akhouayri, L., et al. 2022. Hum Genomics. 16: 70. PMID: 36536459
- Local inhibition of sebaceous gland growth by topically applied RU 58841. | Matias, JR. and Gaillard, M. 1995. Ann N Y Acad Sci. 761: 56-65. PMID: 7625751
- Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: relation of their systemic activity to the formation of a common metabolite. | Cousty-Berlin, D., et al. 1994. J Steroid Biochem Mol Biol. 51: 47-55. PMID: 7947350
- RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism. | Battmann, T., et al. 1994. J Steroid Biochem Mol Biol. 48: 55-60. PMID: 8136306
- Importance of sebaceous glands in cutaneous penetration of an antiandrogen: target effect of liposomes. | Bernard, E., et al. 1997. J Pharm Sci. 86: 573-8. PMID: 9145381
- A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice. | De Brouwer, B., et al. 1997. Br J Dermatol. 137: 699-702. PMID: 9415227
- Effects of topical antiandrogen and 5-alpha-reductase inhibitors on sebaceous glands in male fuzzy rats. | Ye, F., et al. 1997. Skin Pharmacol. 10: 288-97. PMID: 9449168
- Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells. | Miyamoto, H., et al. 1998. Proc Natl Acad Sci U S A. 95: 7379-84. PMID: 9636157
- Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques. | Pan, HJ., et al. 1998. Endocrine. 9: 39-43. PMID: 9798729
Inhibitor of:
CYP26B1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RU58841, 5 mg | sc-482732 | 5 mg | $228.00 |