Date published: 2025-10-17

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RU 24969 hemisuccinate (CAS 107008-28-6)

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Alternate Names:
5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole hemisuccinate
Application:
RU 24969 hemisuccinate is a SR-1A and SR-1B, and moderate SR-2C agonist
CAS Number:
107008-28-6
Purity:
≥99%
Molecular Weight:
287.34
Molecular Formula:
C14H16N2O•½C4H6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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RU 24969 hemisuccinate stands as a notable chemical entity primarily due to its high affinity and potent agonistic action towards the SR-1A and SR-1B receptors, alongside a moderate affinity towards SR-2C receptors, highlighting its intricate involvement in the modulation of serotonin pathways. Its capability to potentially facilitate the release of serotonin further underscores its significance in the intricate dance of neurotransmitter regulation, providing a pivotal tool for dissecting the nuances of serotonin′s roles within various biochemical and neurochemical processes. Additionally, its recognition as a substrate for the human serotonin transporter (SERT) places it at a critical junction of research interest, offering a unique vantage point for investigating the transport mechanisms that underlie serotonin reuptake and distribution, a process for maintaining neurotransmitter balance and function within the synaptic cleft.


RU 24969 hemisuccinate (CAS 107008-28-6) References

  1. Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity.  |  Assié, MB., et al. 1999. Eur J Pharmacol. 386: 97-103. PMID: 10611469
  2. Effect of 5-HT(1B) receptor ligands on self-administration of ethanol in an operant procedure in rats.  |  Tomkins, DM. and O'Neill, MF. 2000. Pharmacol Biochem Behav. 66: 129-36. PMID: 10837852
  3. [(3)H]-8-OH-DPAT binding in the rat brain raphe area: involvement of 5-HT(1A) and non-5-HT(1A) receptors.  |  Assié, MB. and Koek, W. 2000. Br J Pharmacol. 130: 1348-52. PMID: 10903975
  4. Subthalamic 5-HT(1A) and 5-HT(1B) receptor modulation of RU 24969-induced behavioral profile in rats.  |  Martinez-Price, DL. and Geyer, MA. 2002. Pharmacol Biochem Behav. 71: 569-80. PMID: 11888548
  5. Serotonin 2C receptor agonists and the behavioural satiety sequence in mice.  |  Hewitt, KN., et al. 2002. Pharmacol Biochem Behav. 71: 691-700. PMID: 11888560
  6. A comparison of the effects of the 5-HT1 agonists TFMPP and RU 24969 on feeding following peripheral or medial hypothalamic injection.  |  Fletcher, PJ., et al. 1992. Brain Res. 580: 265-72. PMID: 1387034
  7. Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice.  |  Unger, EL., et al. 2006. Neurobiol Dis. 21: 431-43. PMID: 16230020
  8. Inhibition of serotonin outflow by nociceptin/orphaninFQ in dorsal raphe nucleus slices from normal and stressed rats: Role of corticotropin releasing factor.  |  Nazzaro, C., et al. 2009. Neurochem Int. 54: 378-84. PMID: 19418633
  9. Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry.  |  Riva, L., et al. 2018. J Virol. 92: PMID: 29491159
  10. Serotonin 5-HT1A and 5-HT1B receptors co-mediate the RU 24969-induced locomotor activity of male and female preweanling rats.  |  McDougall, SA., et al. 2020. Pharmacol Biochem Behav. 189: 172857. PMID: 31958472
  11. Effects of repeated RU 24969 treatment on the locomotor activity, motoric capacity, and axillary temperatures of male and female preweanling rats.  |  McDougall, SA., et al. 2021. Behav Brain Res. 398: 112982. PMID: 33166571
  12. Importance of dopaminergic neurotransmission for the RU 24969-induced locomotor activity of male and female rats during the preweanling period.  |  McDougall, SA., et al. 2021. Naunyn Schmiedebergs Arch Pharmacol. 394: 903-913. PMID: 33205248
  13. Reciprocal cross-sensitization between cocaine and RU 24969 in male and female preweanling rats.  |  McDougall, SA., et al. 2021. Pharmacol Biochem Behav. 209: 173265. PMID: 34437872
  14. Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine1E-like serotonin receptor.  |  Gudermann, T., et al. 1993. Mol Pharmacol. 43: 412-8. PMID: 8450834

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

RU 24969 hemisuccinate, 10 mg

sc-204896
10 mg
$97.00
US: Only available in the US

RU 24969 hemisuccinate, 50 mg

sc-204896A
50 mg
$548.00
US: Only available in the US