RTK Antibody (IVF6): sc-73523

RTK Antibody (IVF6) is a mouse monoclonal IgG1 antibody that detects RTK protein of Geodia cydonium origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-RTK antibody (IVF6) is available as non-conjugated format. RTK protein, a receptor tyrosine kinase, plays a crucial role in cellular communication and signaling, vital for processes such as cell growth, differentiation, and metabolism. Located on the cell surface, RTK proteins are high-affinity receptors that interact with various ligands, including cytokines and growth factors, initiating a cascade of phosphorylation events that activate downstream signaling pathways. RTK protein structure includes an extracellular domain, a transmembrane region, and a tyrosine kinase domain, essential for signal transduction. Immunoglobulin-like domains in RTK protein of Geodia cydonium highlight evolutionary significance and functional similarities to eukaryotic RTKs, underscoring RTK′s importance in mediating cellular responses to external stimuli.

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RTK Antibody (IVF6) References:

1. Towards an understanding of the molecular basis of immune responses in sponges: the marine demosponge Geodia cydonium as a model.  |  Müller, WE., et al. 1999. Microsc Res Tech. 44: 219-36. PMID: 10098924
2. Cloning and expression of new receptors belonging to the immunoglobulin superfamily from the marine sponge Geodia cydonium.  |  Blumbach, B., et al. 1999. Immunogenetics. 49: 751-63. PMID: 10398802
3. Increased expression of integrin and receptor tyrosine kinase genes during autograft fusion in the sponge Geodia cydonium.  |  Wimmer, W., et al. 1999. Cell Adhes Commun. 7: 111-24. PMID: 10427964
4. Gene structure and function of tyrosine kinases in the marine sponge Geodia cydonium: autapomorphic characters in Metazoa.  |  Müller, WE., et al. 1999. Gene. 238: 179-93. PMID: 10570996
5. Receptor tyrosine kinase, an autapomorphic character of metazoa: identification in marine sponges.  |  Müller, WE., et al. 1999. Acta Biol Hung. 50: 395-411. PMID: 10735175
6. Immunoglobulin-like domain is present in the extracellular part of the receptor tyrosine kinase from the marine sponge Geodia cydonium.  |  Schäcke, H., et al. 1994. J Mol Recognit. 7: 273-6. PMID: 7734153
7. Characterization of the receptor protein-tyrosine kinase gene from the marine sponge Geodia cydonium.  |  Müller, WE. and Schäcke, H. 1996. Prog Mol Subcell Biol. 17: 183-208. PMID: 8822805
8. Immunochemical localization of the phylogenetically oldest receptor tyrosine kinase: existence in the marine sponge Geodia cydonium.  |  Skorokhod, A., et al. 1997. Cell Mol Biol (Noisy-le-grand). 43: 509-19. PMID: 9220144
9. Origin of metazoan adhesion molecules and adhesion receptors as deduced from cDNA analyses in the marine sponge Geodia cydonium: a review.  |  Müller, WE. 1997. Cell Tissue Res. 289: 383-95. PMID: 9232818