Date published: 2025-11-3

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RTI-55 hydrochloride (CAS 141899-24-3)

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Alternate Names:
(1R,2S,3S,5S)-3-(4-Iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Ester Hydrochloride; [1R-(exo,exo)]-3-(4-Iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Ester Hydrochloride; RTI 4229-98 Hydrochloride; β-CIT Hydrochloride
CAS Number:
141899-24-3
Molecular Weight:
421.70
Molecular Formula:
C16H20INO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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RTI-55 Hydrochloride, falls within the phenyltropane class, functions by significantly blocking the dopamine transporter. This transporter plays a key role in regulating dopamine reabsorption in the brain. By inhibiting this process, RTI-55 Hydrochloride contributes to heightened dopamine presence, leading to an elevated concentration of this neurotransmitter.


RTI-55 hydrochloride (CAS 141899-24-3) References

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  2. Reinstatement of extinguished drug-taking behavior in rats: effect of the kappa-opioid receptor agonist, U69593.  |  Schenk, S., et al. 2000. Psychopharmacology (Berl). 151: 85-90. PMID: 10958121
  3. Sensitivity of binding of high-affinity dopamine receptor radioligands to increased synaptic dopamine.  |  Gatley, SJ., et al. 2000. Synapse. 38: 483-8. PMID: 11044896
  4. Mechanisms of cocaine-induced decreases in immune cell function.  |  Pellegrino, TC., et al. 2001. Int Immunopharmacol. 1: 665-75. PMID: 11357879
  5. Locomotor stimulant effects of novel phenyltropanes in the mouse.  |  Kimmel, HL., et al. 2001. Drug Alcohol Depend. 65: 25-36. PMID: 11714587
  6. Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.  |  Henry, LK., et al. 2006. J Biol Chem. 281: 2012-23. PMID: 16272152
  7. Dissection of an allosteric mechanism on the serotonin transporter: a cross-species study.  |  Neubauer, HA., et al. 2006. Mol Pharmacol. 69: 1242-50. PMID: 16434615
  8. Studies of the biogenic amine transporters. 12. Identification of novel partial inhibitors of amphetamine-induced dopamine release.  |  Pariser, JJ., et al. 2008. J Pharmacol Exp Ther. 326: 286-95. PMID: 18441249
  9. β-Phenylethylamine requires the dopamine transporter to increase extracellular dopamine in Caenorhabditis elegans dopaminergic neurons.  |  Hossain, M., et al. 2014. Neurochem Int. 73: 27-31. PMID: 24161617
  10. The compulsion zone explains the self-administration of cocaine, RTI-55 and bupropion in rats.  |  Zinani, DB., et al. 2022. Brain Res. 1774: 147707. PMID: 34736890
  11. Sodium- and chloride-dependent, cocaine-sensitive, high-affinity binding of nisoxetine to the human placental norepinephrine transporter.  |  Jayanthi, LD., et al. 1993. Biochemistry. 32: 12178-85. PMID: 8218295
  12. Cocaine cross-sensitization to dopamine uptake inhibitors: unique effects of GBR12909.  |  Elmer, GI., et al. 1996. Pharmacol Biochem Behav. 53: 911-8. PMID: 8801597
  13. Displacement of RTI-55 from the dopamine transporter by cocaine.  |  Gatley, SJ., et al. 1996. Eur J Pharmacol. 296: 145-51. PMID: 8838450
  14. Direct approach for attenuating cocaine's effects on extracellular dopamine: targeting the dopamine transporter.  |  Morgan, AE., et al. 1997. Synapse. 26: 423-7. PMID: 9215601
  15. Positron emission tomography radioligands for dopamine transporters and studies in human and nonhuman primates.  |  Volkow, ND., et al. 1998. Adv Pharmacol. 42: 211-4. PMID: 9327881

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

RTI-55 hydrochloride, 10 mg

sc-472826
10 mg
$400.00