RTI-113 (CAS 141807-57-0)
Alternate Names:
(1R,2S,3S,5S)-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Phenyl Ester Hydrochloride; [1R-(exo,exo)]-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Phenyl Ester Hydrochloride; RTI 113; RTI 4229-113
CAS Number:
141807-57-0
Molecular Weight:
392.32
Molecular Formula:
C21H22ClNO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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RTI-113 is a chemical compound used as a research tool in the field of neuroscience and biochemistry, particularly concerning the study of the dopamine transporter (DAT). It serves as a potent and selective inhibitor of DAT, which is a key protein involved in the regulation of dopaminergic signaling in the brain. Researchers use RTI-113 to investigate the neurochemical mechanisms underlying dopamine-related functions and to elucidate the pathophysiology of conditions associated with dopaminergic dysregulation. Additionally, RTI-113 is applied in the development and refinement of imaging techniques, such as positron emission tomography (PET), to visualize DAT distribution in the brain. Studies involving RTI-113 contribute to the understanding of neurological conditions where dopamine transport plays a significant role.
RTI-113 (CAS 141807-57-0) References
- Comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor RTI-113 in the squirrel monkey. | Howell, LL., et al. 2000. J Pharmacol Exp Ther. 292: 521-9. PMID: 10640288
- Locomotor stimulant effects of novel phenyltropanes in the mouse. | Kimmel, HL., et al. 2001. Drug Alcohol Depend. 65: 25-36. PMID: 11714587
- Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys. | Wilcox, KM., et al. 2002. Synapse. 43: 78-85. PMID: 11746736
- RTI 113, a 3-phenyltropane analog, produces long-lasting cocaine-like discriminative stimulus effects in rats and squirrel monkeys. | Cook, CD., et al. 2002. Eur J Pharmacol. 442: 93-8. PMID: 12020686
- Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters. | Jarkas, N., et al. 2005. Nucl Med Biol. 32: 211-24. PMID: 15820756
- Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys. | Kimmel, HL., et al. 2008. Pharmacol Biochem Behav. 90: 453-62. PMID: 18468667
- Some effects of dopamine transporter and receptor ligands on discriminative stimulus, physiologic, and directly observable indices of opioid withdrawal in rhesus monkeys. | McMahon, LR., et al. 2009. Psychopharmacology (Berl). 203: 411-20. PMID: 18636243
- Effects of the monoamine uptake inhibitors RTI-112 and RTI-113 on cocaine- and food-maintained responding in rhesus monkeys. | Negus, SS., et al. 2009. Pharmacol Biochem Behav. 91: 333-8. PMID: 18755212
- Interaction of tyrosine 151 in norepinephrine transporter with the 2β group of cocaine analog RTI-113. | Hill, ER., et al. 2011. Neuropharmacology. 61: 112-20. PMID: 21420984
- Interactions between dopamine transporter and cannabinoid receptor ligands in rhesus monkeys. | Schulze, DR., et al. 2012. Psychopharmacology (Berl). 222: 425-38. PMID: 22374253
- Effects of monoamine reuptake inhibitors in assays of acute pain-stimulated and pain-depressed behavior in rats. | Rosenberg, MB., et al. 2013. J Pain. 14: 246-59. PMID: 23332494
- Cocaine withdrawal alters the reward omission effect and enhances traits of negative urgency in rats across multiple days of testing. | Barker, AT. and Rebec, GV. 2016. Drug Alcohol Depend. 163 Suppl 1: S19-24. PMID: 27306726
- Serotonin transporter inhibition and 5-HT2C receptor activation drive loss of cocaine-induced locomotor activation in DAT Val559 mice. | Stewart, A., et al. 2019. Neuropsychopharmacology. 44: 994-1006. PMID: 30578419
- Locomotor stimulant effects of cocaine and novel cocaine analogs in DBA/2J and C57BL/6J inbred mice. | Tolliver, BK. and Carney, JM. 1995. Pharmacol Biochem Behav. 50: 163-9. PMID: 7740054
- RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter. | Dworkin, SI., et al. 1998. Synapse. 30: 49-55. PMID: 9704880
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RTI-113, 5 mg | sc-472880 | 5 mg | $322.00 |